The Characteristics Of Clinical And Pathology And The Patients With Recurrent Glomerulonephritis Posttransplantation Or De Novo Glomerulonephritis Posttransplantation

Objective:1.To explore the characteristics of clinical and pathology and prognosis in patients with Recurrent glomerulonephritis posttransplantation(RGP) or De novo glomerulone phritis Posttransplantation(DNGP);2.To explore the characteristics of Traditional Chinese Medicine(TCM) syndromes in patients with(RGP)or(DNGP),and provide a reference index for the cue of(RGP)or(DNGP).Materials and methods:1.Select the patients who were done the Kidney biopsy from January 2004 to February 2009,in the Fuzhou General Hospital Department of Urology 74 cases,the patients with(RGP)or(DNGP)34(group A).the others are non-(RGP) or(DNGP)40 (group B).At the same time,Select the patients whose kidney come from The same kidney donor25(group c);2.Observe all patients 'age,agender,Retransplantation,graft survival after transplantation 1 yeat,3 years,5years,Scr,BUN,Urinary protein before Kidney puncture。3.1 week before Kidney puncture,analysis the type distribution of the characteristics of TCM of patients group A.Results:1.Three groups have no difference with age,gender,PRA,times of transplantation and(P>0.05).2.Three groups have significance difference with SCr and BUN Kidney puncture 1 week ago(P<0.05),group A>group B(P<0.05),group A>group C(P<0.05), group B>group C(P<0.05),group A of puncture 1 week before urine protein levels were significantly greater than the C group(P<0.05),no obvious difference between other groups; 3.1 year,3-years Graft survival rate was no significant difference(P>0.05);but the graft survival ratio of group A was lower than group C(P<0.05) in 5 years.(P<0.05),no obvious difference between other groups;4.The Pathological types of the patiens group A is as fllows: FSGS 7(20.59%),IgAN 10(29.41%),MN 5(14.71%),MPGN 6(17.65%), MsPGN 6(18.18%),SLE-LN1(2.94%);5.The distribution proportion of TCM syndrome of the patiens with group A as fllows:spleen-kidney qi deficieney8(23.53%),Liver kidney yin deficieney 12(35.3%),syndrome of blood stasis8(52.94%),syndrome of qi-yin deficieney3(8.82%),intrinsic heat-yin deficieneyl(2.94%).Conclusion:1.when the patiants whose renal function is abnormal,the Scr,BUN and the urine protein levels of A Groups is higher than The C Groups.2.There is no effect for Allograft nephropathy on a short-term survival,but,which can effect Allograft nephropathy's long-term survival;3.FSGS,IgAN,MN,MPGN,SLE-LN,MSPGN are the the common type of (RGP)or(DNGP);4.The distribution proportion of TCM syndrome of the patiens with (RGP)or(DNGP)is as fllows:spleen-kidney qi deficiency8(23.53%),Liver-kidney yin deficiency 12(35.3%),syndrome of blood stasis8(52.94%),syndrome of qi-yin deficiency3(8.82%),intrinsic heat-yin deficieneyl(2.94%).