Occult Nephritis Clinical And Pathological Features Of Tcm Syndrome Type And Renal Pathology Research

Latent glomerulonephritis, including asymptomatic hematuria andasymptomatic proteinuri with or wi thout asymptomatic hematuria,in fact,it includea group of glomerular diseases of different etiology and pathogenesis。Most scholarsconsidered that it's clinical symptoms are mild and sometimes can self -healing。themajority of scholars believe that this d isease does not require special treatment, and ithas a good prognosis。However, some scholars believe that the disease is a chronicglomerulonephritis, the prognosis is not good, a considerable number of patients mayprogress to end-stage renal disease, and proposed to remove the name of Latentglomerulonephritis. Nevertheless, Latent glomerulonephritis as a common clinicalphenomenon, it is necessary to analysis the clinical and pathological features and therelationship between them further in -depth。We also need to analysis the relationshipbetween syndrome differentiation of Chinese medicine and the kidney pathology. Thisstudy is done on the basis of my tutor's experience about Latent glomerulonephritis,through retrospective analysis,study further the relationship both between clinicaland pathological features o and the relationship between syndrome differentiation andkidney pathology features。Objective:To investigate clinical and pathological features of Latentglomerulonephritis,Preliminary study the correlation between clinical features withrenal pathological of Latent glomerulonephritis。Preliminary study the correlationbetween syndrome differentiation with kidney pathology ofLatentglomerulonephritis。Methods:The retrospective study,pathological semi-quantitive scores byKatafuchi methodology,investigate clinical and pathological features of Latentglomerulonephritis,Analysis the correlation between the following factors(the courseof disease,age,Scr,BUN,24-hour urine protein,the severity of proteinuria,gross hematuria,the syndrome differentiation)and kidney pathologicalsemi-quantitive scores。Results:①clinical features: 48 patients most of the performance is the patientsboth have asymptomatic hematuria and asymptomatic proteinuria,followed bywho only have asymptomatic hematuria and who only have proteinuria simply seeless. Most patients have mild to moderate proteinuria, a considerable portion of 48patients have a gross hematuria in the course. Deficiency of both qi and yin isthe most common Syndrome of deficiency in oringin, damp-heat is the most common Syndrome of sthenia syndrome。②pathological features: the most common pathologicdiagnosis of IgA nephropathy(IgAN), followed by mesangial proliferative glomerulonephritis(MSPGN), the majority of pathological changes are mild kidney damage ,and often merger mild renal tubular in jury。Some patients'pathological changes areheavier, IgALee III-I V class.③kidney pathology and clinical features correlation anal -ysis: age,the course of disease,BUN and kidney pathology total score are not sig -nificant correlation (P>0.05), 24-hour urine protein,Scr and renal pathology total scorewas significantly nonlinear correlation (P <0.01)；kidney pathological changes are heavierof patients who have asymptomatic proteinuria with or without hematuria thanpatients who only have asymptomati c hematuria；Proteinuria is the risk factor ofglomerular and tubulointerstitial damage (P< 0.05), and effect on renal vascular wasnot significant (P > 0.05),the severity of proteinuria and renal pathology the severityof the injury are not significant correlation ( P> 0.05)；gross hematuria was not relatedto the severity of the injury (P> 0.05), It seems that gross hematuria can't determinethe prognosis；There is a significant differrence between damp-turbidity and damphot(P <0.05) comparing the remaining group, there was no significant difference bothdeficiency in oringin and sthenia syndrome (P> 0.05). The results suggested that: Defi -ciency syndromes of deficiency in oringin have similar impact on renal pathologydamage, and damp- turbi- dity may be a key factor lead to renal pathology damage。Conclusion: Deficiency syndromes of deficiency in oringin have similarimpact on renal pathology damage, and damp -turbidity may be a key factor lead torenal pathology damage。damp-turbidity may be a key factor lead to renal pathologydamage。According to distribution characteristics of syndrome differentiationinvigorating qi,nourishing yin,promoting blood flow and removing dampness is themain treatment of Chinese medicine。Proteinuria,Scr is the main risk factor of Latent glomerulonephritis, age, courseof disease, BUN and gross hematuria are no significant correlate with renal pathologydamage. the severity of proteinuria and renal pathology severity of the injury have notobvious relationship。sometimes clinical appearance is mild while pathologicaldamage is serious。...