Significance Of CD44V6 And Ezrin Expression In Human Non-Small Cell Lung Cancer

Objective:To study the expression of CD44V6 and Ezrin in human non-small cell lung cancer.Methods : CD44V6 and Ezrin were detected by two-step immunohistochemical staining technique in tumor tissues from 65lung cancer cases and in normal lung tissues from 15 cases with benign disease and analyzed by the lung cancer clinicopathologic characteristics.Results:The positive rate of CD44v6 expression in NSCLC was 69.23%,and no distinct was detected in the normal lung tissues.The up–regulated of CD44V6 expression was significantly correlated with lymph node metastasis and distant metastasis and was not correlated with pathological type, the degree of differentiation of tissue and clinical stage.The positive incidence of ezrin expression (72.3%)was significantly lower in lung cancer tissues than that in normal tissues (100%)(p<0.05),and the down regulated of ezrin expression was significantly correlated with lymph node metastasis and distant metastasis and was not correlated with pathological type, the degree of differentiation of tissue and clinical stage. Otherwise , ezrin expression in lung cancer from cell membrance to cell plasma.Conclusion: CD44V6 and Ezrin are involved in carcinogenesis. The levels of CD44V6 and Ezrin may be a sensitive predictor of metastasis and prognosis in NSCLC.