Clinical Analysis Of The Screening For 22 Colorectal Cancer Family With MSI

ObjectiveColorectal cancer (CRC) is one of the most common malignant tumors. The aim of this research is to estimate the clinical value of MSI detection in the screening of HNPCC patient and patients in the case which with familial predisposition and comfirmed as MSI by the progress of PCR-SSCP.MethodsWe followed up 21 MSI positive CRC patients' families which was with familial predisposition by 5 years, and applied colonoscope to screen the CRC patients in the 63 primary relatives. The tissue abtained from colonoscope were diagnose by sheet HE staining.ResultsOf the 66 cases ,three cases were occurred HNPCC associated cancer between 2003 and 2009, one (1/66) was colon cancer, one (1/66) was rectal cancer,one was endometrial cancer. In the remain 63 cases, one (1/66 (1/66) was final diagnosed as in situ colon carcinoma,another seven (7/66) cases were diagnosed colorectal polypi,4 families were classified as HNPCC family.ConclusionsDirect relatives of MSI positive CRC patients are high-risk population of HNPCC. Follow up the high-risk population may find the earlier colorectal cancer.