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Effect Of Ionizing Radiation On Hematopoietic System

Posted on:2010-01-24Degree:MasterType:Thesis
Country:ChinaCandidate:X P ZhangFull Text:PDF
GTID:2144360302968613Subject:Epidemiology and Health Statistics
Abstract/Summary:PDF Full Text Request
ObjectiveTo find about the impact of long term low dose of ionizing radiation to cytogenetic inheritance damage on occupational workers. And to offer pertinence advise and gist for constituting radioactive protection measure.MethodsMedical radiation exposed persons were chosen by epidemiological prevalence study. Workers were divided into five groups according to type of radiation work. The doses were routinely detected in the radiation workers by carrying out individual thermoluminiscent dosimeter"TLD model 469",and the results were dealt with the"TLP-hot light lamination dose data disposal system". The chromosome aberrations and micronucleus were monitored using routine whole blood microculture method. The interrelated indexes of health warship were examined.Analysis is conducted for getting descriptive statistics of the data, and used t-test, ANOVA,χ2-test and so on with SPSS 13.0 and PEMS 3.1 statistical software.Results(1) Survey of sources of internal medicine, radiation oncology, diagnostic radiology, interventional radiology and clinical nuclear medicine. By chi-square test found that the group posed no significant number of people, each group selected a more balanced number. Survey the gender composition among the three groups, age did not constitute a statistical significance (P> 0.05), selected survey has good comparability.(2) Of the contact 3-ray group on dose equivalent and dose equivalent in inter-group differences were statistically significant (P <0.05). The highest of which is the radiation oncology group, followed by interventional radiology and nuclear medicine clinical group, the lowest group is Diagnostic Radiology. Survey-ray exposure by the division between men and women, all contacts between men and women dose equivalent is not statistically significant (P> 0.05).(3) Group work, the routine indicator of WBC, HGB, MCH, MCHC, MO, PCT, MPV, PDW and other indicators of 8 there is a difference between groups, with statistical significance (P <0.05) .(4) The rate of chromosomal aberrations in each group and the total chromosome aberration rate in general have statistical significance (P <0.05). Division by sex survey revealed that chromosome aberrations between men and women and no difference between the total chromosomal aberrations (P> 0.05). Described in terms of gender, the occurrence of chromosome aberrations and the total probability of the same chromosomal aberrations.(5) In the micro-nucleated cells within the scientific group on the micro-cell is smaller than the number of Diagnostic Radiology Unit, clinical nuclear medicine group, interventional radiology and radiation oncology group, the difference was statistically significant (P <0.05) . Description of staff radiation exposure effects than non-radiation workers. Between men and women but the survey micro-nucleated cells there was no difference (P> 0.05).ConclusionFinally, the study has come to some conclusions that are mainly as followed: (1) Ionizing radiation (occupational exposure) on the radiological health staff have a certain impact. (2) Engaged in different jobs by the Radiation Workers in the ionizing radiation (occupational exposure) produced by different radiation damage. (3) Detection of radiation workers physical indicators of different radiosensitivity. (4) Caused by radiation damage and micronuclei in peripheral blood as the change between the two are linked to the high rate of micronucleus hematopoietic system radiology staff more serious injury, interleukin abnormal rate of increase. Ray exposure age, WBC, GR and micronuclei frequency was related to low-grade. (5) Lower than the dose recommended by International Commission on Radiological Protection level of occupational exposure to 50 mSv / a, the radiology staff (professional groups) in peripheral blood of chromosomal aberrations, micronuclei and health-related indicators have shown a change in varying degrees, indicating that the existing international radiological protection standards to be further explored.
Keywords/Search Tags:Ionization radiation, prevalence study, dose equivalent, chromosome aberration, micronucleus
PDF Full Text Request
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