The Relationships Of Oral Glucose Tolerance Test And Pregnant Prothrombotic State

ObjectiveTo study the relationships of oral glucose tolerance test(OGTT) in second trimester and prothrombotic state in third trimester.MethodsAccording to the results of 75g-OGTT in pregnant 24-28 weeks,100 pregnant women with abnormal glucose screening were divided into three groups:normal glucose tolerance(NGT) group,gestational impaired glucose tolerance(GIGT) group and geatational diabetes mellitus(GDM) group,calculate area under curve of OGTT(AUC-OGTT).To detect partial prothrombotic state parameters before deliver,including hematocrit(HCT),platelet count(PLT),mean platelet volume(MPV),prothrobin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fg),D-Dimer and triglyceride(TG),compare them among three groups,make correlation analysis between fasting,1h,2h,3h,AUC-OGTT and prothrombotic state parameters.ResultsIn GDM group,PLT,PT,APTT were significantly lower than in NGT and GIGT groups(P<0.05),while MPV,Fg,D-Dimer,TG were significantly higher than in NGT and GIGT groups(P<0.05); In GDM group,HCT was significantly higher than in GIGT groups(P<0.05); AUC-OCTT had positive correlations with HCT,MPV,Fg,D-Dimer and TG,but had negative correlations with PLT,PT and APTT,moreover AUC-OGTT had positive correlation with number of abnomal parameters.ConclusionPregnant women with abnormal OGTT had obvious prothrombotic state,AUC-OGTT could predict risk of thrombosis in third trimester.