| ObjectiveThis study was designed to collect and analyze Hospital of Guangdong Province in October 2007-2010 years in February hospitalized cases of cancer chemotherapy, the use of Chinese medicine theory and the method of combining Chinese and Western Medicine, in theory, clinical studies of chemotherapy both in depth the most common bone marrow suppression side-effects of etiology and pathogenesis and control issues. That "spleen and kidney deficiency" is a major bone marrow suppression after chemotherapy, pathogenesis, clinical terms "spleen qi, Bushentianjing blood and new" as the main treatment, development of "protecting marrow side" with chemotherapy, observed by Traditional Chinese Medicine Clinical bone marrow suppression caused by chemotherapy.MethodsThis study was a randomized, controlled, double-blind, exploratory approach, the object is to Guangdong Provincial Hospital of 2007-2010 non-small cell lung cancer, colon cancer, stomach cancer, breast cancer chemotherapy patients hospitalized a total of 120 patients were randomly divided into two group,65 cases in which the observation group,55 patients in control group, two groups were given conventional chemotherapy regimen. On the basis of the control group given chemotherapy Diyushengbaipian control bone marrow suppression; observation group based on the increase in chemotherapy prescriptions self service "care marrow side". Observation of a chemotherapy cycle, patients were compared chemotherapy, hematological toxicity and its sub-degree, the incidence of other toxicity, physical response, quality of life and Karnofsky score changes in immune function. Results1.Blood Change Analysis:After chemotherapy, blood days after 3,7,10,15,21 observations in the observation group leukocyte, granulocyte and granulocyte count decreased more significantly than the control group (P<0.05); but there were changes in hemoglobin and platelet range was no significant difference (P>0.05);2. TCM symptom improvement:the observation group Shenpi fatigue, less gas lazy words, weak waist, loss of appetite, palpitations shortness of breath, chills and other symptoms of cold cured after treatment than before treatment significantly improved (P<0.05), while the control group There was no significant difference between before and after treatment (P>0.05). Traditional test group shows a marked improvement of symptoms than the control group, spleen and kidney Huayu decoction treatment is effective;3. The quality of life:the observation group after treatment, KPS score significantly higher than those in control group (P<0.001), weight stable situation than the control group (P<0.05), shows up spleen Blood can only significantly increased in renal patients with physical status;4. Toxicities:the observation group after treatment, nausea and vomiting was significantly lower than the control group (P<0.05), but liver function, kidney function, urine routine, stool routine, the two groups no significant difference (P>0.05).ConclusionsThe clinical studies showed that:â‘ spleen and kidney and stasis can only prevent chemotherapy neutropenia, reduce the chemotherapy from the cell reduction.â‘¡Spleen Journal of Traditional Chinese Medicine Shenpi to effectively alleviate the fatigue, less gas lazy words, weak waist, loss of appetite, palpitations shortness of breath, chills and other symptoms of cold cured to improve the physical condition of patients and improve quality of life.â‘¢Reinforcing Kidney Blood safety, no significant side effects.
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