The Study Of Correlation Between Regional Cerebral Blood Flow And Degree Of Brain Tissue Injury Of Interictal Epileptic Activity In Patients With Epilepsy

Objective Patients with epilepsy have brain injury,the single-photon emission-computed tomography (SPECT) can make a location diagnosis to it.The aim is to explore the correlation between dynamic change of regional cerebral blood flow(rCBF) and degree of brain tissue injury of interictal epileptic activity in patients with epilepsy during the treatment of different state by antiepileptic drugs.Methods Serum protein level of s-100βwas determined by double antibody sandwish enzyme-linked immunosorbent assay(ELISA) in 48 cases of interictal epileptic activity in patients with epilepsy and 30 healthy person. SPECT rCBF imaging was performed in 48 cases in patients with epilepsy,the vision and semi-quantitative analysis were used in photograph reading and region of interest (ROI) technology, respectively. Statistical analysis was performed with SPSS 11.0.Results The protein level of s-100βin serum in patients of interictal epileptic activity was significantly higher than that of control group(t= 9.96, P< 0.01). According to epilepsy control criteria,complete control were 20 cases, excellent control and effective control were 18 cases, and invalid were 10 cases; protein level of s-100βand the percentage of changed rCBF of invalid group was significantly higher than that of other two groups(P< 0.01). Protein level of s-100βin serum and the percentage of changed rCBF of epilepsy showed highly positive correlation(r= 0.887,P<0.01).Conclusions Protein level of s-100βin serum associated with rCBF in SPECT imaging,which can make a quantitative and location diagnosis and evaluate brain injury to epilepsy-induced brain damage,can be as another means of monitoring the efficacy of treatment by antiepileptic drugs in patients with epilepsy.