| Objective:To investigate the methods of anesthetic and cardiopulmonary bypass(CPB) management for beating heart surgery in minipigs.Methods:Twelve minipigs were involved in the experiment, set up CPB plumbing with routine method, blockage superior and inferior vena cava cannulas with out ascending aorta cannula, execution of tricuspid valve plasty with beating heart. The proposal of anesthesia is isoflurane-based inhalated combined intravenous injected, induction with ketamine intramuscular and Pentobarbital injected intravenously; maintenance with isoflurance1.0-1.5MAC inhalated, fentanyl 15-20ug·kg-1·h-1, midazolam 0.1-0.2ug·kg-1·h-1 and pipecuronium 10-0.15ug·kg-1·h-1 injected inconsecutively. Rectal temperature was maintained between 35-37℃during CPB procedure, flow volumes were 60-80 ml·kg-1·h-1,mean arterial blood pressure were 5.33-9.33kPa (60-90mmHg), hemoglobin concentration were 60-80g/L, Hct were 25-30%. Invasive blood pressure, blood gas analysis were detected. Times on induction and maintenance of anesthesia, time of CPB and ventilator procedure were recorded. Complications of anesthesia and CPB were obtained as well.Results:Time on induction and maintenance of anesthesia were 10.0±2.9min and 83.4±8.0min, time of CPB and ventilator procedure were 248.7±46.8min and 344.3±37.5min, hemodynamics were maintained stabled, lactic acid values were increased signifcantly after CPB cessation and decreased to the foundation level after the period of chest-closed; hemoglobin concentration and Hct were lower during CPB procedure and achived to normal state after CPB cessation.Conclusion:Isoflurane-based inhalated combined intravenous injected anesthesia were effective, maintained hemodynamics stablely, time on palinesthesia were shorter; CPB procedure has less influence on circulation, respiratory, and tissue metabolism, it takes less complications.The method of anesthetic and CPB management are reasonable choice for open heart operation with beating heart.
|
PDF Full Text Request