Detection Of Plasma Visfatin In Relation To Insulin Resistance And Obesity In Women With Polycystic Ovary Syndrome

Objective:The present study was undertaken to investigate the plasma visfatin in relation to insulin resistance, obesity and marker of hyper andro-genism in women with polycystic ovary syndrome.Methods:The study group consisted of 42 women with PCOS and 34 cases without PCOS, and the women with PCOS were classified as follows: 21 insulin resistance (IR) and 21 non-insulin resistance,19 obese and 23 normal weight. Plasma visfatin concentrations were assayed by ELISA, and fasting plasma glucose, serum insulin were measured.Results:Plasma visfatin levels were significantly higher in women with PCOS than control, and plasma visfatin levels were significantly higher in obses women than non-obese cases with PCOS. Plasma visfatin levels were significantly higher in IR women with PCOS than non-IR cases, and the case is as in non-obese patients with PCOS and non-obese controls. The comparison between groups was statistically significant (P<0.05). Pla-sma visfatin levels were found to be positively correlated with BMI(r=0.421, P=0.006), WHR(r=0.418, P=0.006), FBG (r=0.35,P=0.023), FINS (r=0.318, P=0.04) and IRI(r=0.365, P=0.018), independently of other potential con-founding factors.Conclusion:The metablism of plasma visfatin in women with poly-cystic ovarian syndrome might be abnormal. Increase in palsma visfatin concentrations might be associated with insulin resistance and obesity in women with polycystic ovarian syndrome, and independently of T.