The Relationship Between Gallstones And Serum Adiponection ,Insulin Resistance As Well As Lipid Abnormalities

ObjectiveTo investigate the correlation between cholesterol gallstones and serum Adiponection,insulin resistance as well as lipid abnormalities.MethodsWe chose 50 patients with cholesterol gallstone patients and 30 cases of control group. All subjects were measured plasma adiponectin(AD),fasting insulin(FINS) and fasting plasma glucose levels(FPG). using enzyme-linked immunosorbentassay. Meanwhile BMI, HOMA-IR, ISI were assayed. Collection of chemical analysis of fresh bile bile cholesterol (CH), bile acid (TBA) and phospholipid (PL) content and calculated cholesterol saturation index (CSI), evaluation of the relationship between the indicators; application of immunohistochemistry to detect CD68 at 50 cases of patients with cholesterol gallstone gallbladder wall (stone group) and 30 cases of the expression of the control group specimens.ResultsThe blood TC ,TG ,HOMA-IR, FINS,BMI, LDL,Bile CH in patients with gallstone was significantly higher than those of normal controls.Against Adiponectin, ISI, HDL, Bile Acids were lower(p<0.05). difference between statistical significance. CD68 in the experimental group, the top side of gallbladder epithelial expression in the control group did not find CD68 expression Conclusion(1) The level serum adiponectin in cholesterol gallstone patients is lower than the controls with significant insulin resistance(p<0.05).(2) The level of serum adiponectin and insulin resistance are significantly correlated with lipid and Cholesterol saturation index(CSI).(3) The level of serum adiponectin,insulin resistance and lipid abnormalities are closely related to the cholesterol gallstone formation.