A Clinical Study On The Coronary Angiographic Features And Cardiovascular Risk Factors In Patients With Acute Coronary Syndrome And Ideal LDL-C

Object: To observe the coronary angiographic features and cardiovascular risk factors in patients with acute coronary syndrome and ideal LDL-C.Methods: Randomly selected 120 patients suffered acute coronary syndrome who were hospitalized in cardiovascular department of the first hospital of Jilin University from January 1st,2009 to January 1st,2010. The LDL-C of 60 of them is ideal. All the patients conform to the diagnostic criteria of acute coronary syndrome. The diagnose of acute myocardial infarction should meet at least two of the following criteria: 1)Typical ischemic chest pain lasts more than 30 minutes; 2)The peak value of CK-MB and CTnI is over twice of the normal top limit;3) ECG ST-T dynamic variation. Unstable angina includes: worsen effort angina,the initial effort angina in three weeks or resting angina in three weeks. According to NCEP ATPⅢ, ideal LDL-C is LDL-C<100 mg/dL( 2.6 mmol/L),nonideal LDL-C is LDL-C≥100 mg/dL( 2.6 mmol/L).To compare the difference of coronary angiographic features, cardiovascular events,other blood fat(TC,TG,HDL-C and Apo-a) between two groups and the dependability with other cardiovascular risk factors(Age>45, Male, Smoking, Obesity, Hypertension, Diabetes, High TG, Low HDL-C).Results: The disparation of total morbid vessels, LAD morbid vessels , LCX morbid vessels, RCA morbid vessels is not statistically significant (P>0.05) between the two groups. The disparation of single morbid vessel , two morbid vessels is not statistically significant(P>0.05)between the two groups.The proportion of three morbid vessels of ideal LDL-C group is smaller than the nonideal LDL-C group(P<0.05). The number of vessles whose stenosis is <50%,50-70%,70-90% is not statistically significant(P>0.05)between the two groups. The proportion of vessel whose stenosis is >90% of ideal LDL-C group is smaller than the nonideal LDL-C group(P<0.05). The disparation of cardiovascular events is not statistically significant (P>0.05)between the two groups.The average TC of ideal LDL-C group is 4.07±0.79mmol/L that is lower than nonideal LDL-C group(P<0.05). The average TG of ideal LDL-C group is 1.60±1.09mmol/L that is lower than nonideal LDL-C group(P<0.05). The disparation of average HDL-C and Apo-a is not statistically significant (P>0.05)between the two groups.The dependability of age>45, male, smoking, hypertension, diabetes, Low HDL-C in ideal LDL-C group is not statistically significant (P>0.05), but the dependability of obesity, high TG in ideal LDL-C group is obviously (P<0.05). The dependability of age>45, male, obesity, high TG, hypertension, Low HDL-C in nonideal LDL-C group is not statistically significant (P>0.05), but the depend- ability of smoking, diabetes in nonideal LDL-C group is obviously(P<0.05).Conclusion: 1. The proportion of three morbid vessels and vessel whose stenosis is >90% of nonideal LDL-C group is lagerer than the ideal LDL-C group. 2.The average TC and TG is higher in nonideal LDL-C group.We should lower TC and TG as well as LDL-C. 3.Obesity and high TG contribute more in ideal LDL-C group,which indicates that to control Obesity and high TG in ideal LDL-C group may decrease the danger of ACS. 4. Smoking and diabetes contribute more in nonideal LDL-C group,which indicates that to control smoking and diabetes in nonideal LDL-C group may decrease the danger of ACS.