Correlation Analysis Between The Monocyte Count/High Density Lipoprotein Cholesterol Ratio And The Severity Of Coronary Artery Disease In Patients With Acute Coronary Syndrome

Objective: To investigate the relationship between mononuclear cell count,high density lipoprotein cholesterol ratio(MHR)and the severity of coronary artery disease in patients with acute coronary syndrome(ACS)and its clinical significance.Methods: Continuous collection of cardiovascular wards in our hospital From July 2016 to July 2017,620 patients diagnosed with acute coronary syndrome(ACS)concurrent coronary angiography(CAG)were enrolled in the experimental group(ACS group)and collected during the same period.426 patients with coronary atherosclerosis who had coronary artery stenosis <50% due to chest pain and coronary angiography showed a control group(CG group).According to the clinical characteristics of patients in ACS group,they were divided into unstable angina group(UA group)in 178 cases,acute non-ST elevation myocardial infarction group(NSTEMI group)in 202 cases and acute ST segment elevation myocardial infarction.Group(STEMI group)240 cases.All selected patients were excluded from other diseases that caused chest pain,such as:pleurisy,spontaneous pneumothorax,hemothorax,acute pericarditis,acute myocarditis,thoracic aortic aneurysm,pulmonary embolism,mediastinalitis,mediastinal emphysema,and mediastinal tumors.Exclude patients with concurrent tumors,systemic immune system diseases,severe infectious diseases,severe traumatic diseases,TIA,stroke,lower extremity vascular embolism,severe liver and renal insufficiency and endocrine diseases.Record the general clinical data of selected patients,such as age,gender,history of related diseases(diabetes,hypertension,and family history)and family history.Selected patients were immediately admitted to hospital to take venous blood tests for myocardial enzymes(CK,CK-MB),troponin(c Tn I),and serum ion potassium sodium chloride.On the second day after fasting,blood was collected on the morning of the second day for brain natriuretic peptide and hypersensitivity.CRP,liver function,blood lipids,renal function,fasting blood glucose,and blood routine.Gensini scores were performed on coronary angiograms of all enrolled patients.SPSS20.0 statistical software was used for statistical analysis of data.The ACS group and the control group were compared for the related data such as monocyte counts,HDL-C,MHR,and Gensini scores,and the high-density lipoprotein cholesterol(HDL-C),monocyte counts,MHR,and Gensini scores of the ACS group.Perform Pearson correlation analysis.Result:Monocyte count,MHR and Gensini scores were higher in the ACS group than in the control group.HDL-C levels were lower in the ACS group than in the control group(P<0.05).The Gensini scores in STEMI and NSTEMI patients were higher than those in UA patients(P<0.05).The monocyte counts in STEMI patients were significantly higher than those in UA and NSTEMI patients(P< 0.05);NSTEMI group monocyte counts were higher than UA group,the difference was statistically significant(P<0.05);STEMI group and NSTEMI group HDL-C levels were lower than UA group,but the difference was not statistically significant(P >0.05);MHR levels in the STEMI group were higher than those in the UA group and the NSTEMI group,with a statistically significant difference.The monocyte level in patients with ACS was positively correlated with the Gensini score(r = 0.196,P <0.05).There was a negative correlation between HDL-C and Gensini scores in patients with ACS(r =-0.168,P <0.05).MHR in patients with ACS was positively correlated with Gensini score(r = 0.272,P < 0.05).Conclusion: There is a positive correlation between MHR and the severity of coronary artery disease in patients with acute coronary syndrome,and there is certain clinical value in assessing the severity of coronary artery disease.