Expression And Their Clinical Significance Of GFAP, S100 And Ki-67 In Human Gliomas

ObjectiveTo examine the expression of GFAP, S100 and Ki-67 in human glioma, to discuss the value of GFAP, S100 and Ki-67 in histological grade and evaluate the clinical significance of them.MethodsHE and immunohistochemical staining technique was used to detect the expression of GFAP, S100 and Ki-67 in 32 patients, who were operated in the 1st Affiliated Hospital of Zhejiang University, College of Medicine, from March 2009 to March 2010. The results of HE and immunohistochemical staining are collected from the patients' pathological reportResultsGFAP, S100 and Ki-67 express in all different grades of human glioma. The total positive rate of GFAP in all peitients is 96.9%. The expression level of S-100 was decreased with the increased grade of malignancy (p<0.05), while the expression level of Ki-67 was increased (p<0.05).ConclusionThe expression of GFAP, S100 and Ki-67 is very important to the pathological diagnosis of human glioma. The expression of S100 and Ki-67 are closely related with pathologic grade of glioma. And the Ki-67's expression level correlates significantly with proliferating activity of glioma cell, which effects the peitients'prognosis.