The S100 And Mmp-7 Expression In Perineural Invasion Of Bile Duct Cancer And Clinical Significance

Objective To study the expressions of S100 and MMP-7 in cholangiocarcinoma and paraneoplastic tissue and their correlation with its pathobiological behavior, perineural invasion and their clinical significance.Methods Using immunohistochemical Elivision^TM Plus method,the expressions of S100 and MMP-7 in cancer and paraneoplastic tissues in 36 patients with cholangiocarcinoma were detected and analyzed based on clinical data.Results The positive rates of S100 and MMP-7 in cancer and paraneoplastic tissues were 61.11%(22/36) and 83.33%(30/36),30.56%(11/36) and 0.0%(0/36), respectively,there was a significant difference between the expression of S100 and MMP-7 in cholangiocarcinoma and its adjacent tissues(x²=6.769,51.429,P＜0.01)..The positive rate of nerve invasion was significantly correlated with S 100(y=0.337,P＜0.05), with MMP-7(y=0.512,P＜0.05).There was a positive correlation between S100 and MMP-7(y=0.048,P＜0.05).The expressions of S100 and MMP-7 were related with patient's survival time,and those with positive expressions had a poor prognosis (X²=9.960,5.984,P＜0.05).Conclusion There were higher expressions of S100 and MMP-7 in cholangiocarcinoma.It could be presumed that the S100 up-regulates the expression of MMP-7 and the high expression of MMP-7 facilitates PNI and metastasis of this condition.The high expressions of S100 and MMP-7 in cholangiocarcinoma are involved in tumor genesis,progression,infiltration and metastasis,which are probably linked to the mechanism of PNI and impacting the patient's prognosis.A combination detection of S100 and MMP-7 conduces to estimation of biological behavior and prediction of the prognosis of this malignant tumor and provide a theoretical reason for postoperative adjunctive therapy.