Association Of Left Ventricular Hypertrophy With Renal Function In Patients With Essential Hypertension

ObjectiveTo investigate association of left ventricular hypertrophy(LVH) with renal function in patients with essential hypertension.Methods318 patiens with essential hypertension hospitalized in the department of Cardiology of the First Affiliated Hospital of China Medical University between 2008 and 2010 were investigated. Estimated glomerular filtration rate(eGFR) was detected by serum creatinine (Scr), age and sex. Left ventricular mass index was determined using echocardiography. Patients were divided into two groups-LVH group and non-LVH group.ResultsAge, Sex, Course, body mass index, systolic blood pressure, diastolic blood pressure, uric acid, total cholesterol, triglyceride, fasting blood glucose between two groups were of no statistically significance. Mean eGFR were 77.43±26.38 mL/min/1.73 m2 in LVH group and 83.74±23.70 mL/min/1.73 m2 in non-LVH group(p>0.05).There were no statistcal significance between two groups. However,the slope of the regression line of eGFR versus age was accentuated(p<0.05) in LVH group (slope valuses of-1.818±0.303ml/min/1.73m2 per year) when compared with non-LVH group (slope valuses of-0.902±0.304 ml/min/1.73m2 per year).Conclusion1.LVH accelerates decline of eGFR with age.2.LVMI appeared to be a potential marker of accelerating age-associated deline of eGFR.