Expression Of CXCL10/IP-10 And CXCL9/MIG And Their Significance In Pathological Scar

ObjectiveTo study the expression of IFN-induced protein of 10 kDa (IP-10) and monokine induced by IFN-y(MIG) in pathological scar and explore their effect in formation of pathological scar.MethodsImmunohistochemical techniques were used to measure the expression and distribution of IP-10 and MIG in 28 cases of keloid (group K),34 cases of hypertrophic scar (group HS) and 20 cases of normal skin (group N), and data were analyzed statistically.ResultsThe expression of IP-10 and MIG in groups K and HS was higher than that in group N and groups K and HS showed a significant difference from group N (P< 0. 005). However, expression was not statistically different between group K and group HS(P>0.05).ConclusionIP-10 and MIG may enhance the formation of pathological scar viahoming T helper (Th) lymphocytes which would result in immunoreactions.