Research On Distributing Rules Of Syndromes Of Traditional Chinese Medicine For Patients With Acute Ischemic Stroke Associated With Hyperlipidaemia (HLP)

Research Background:To control blood lipids is one important means in modern medicine for the preventive treatment of ischemic stroke. Based on a large number of documents, the paper systematically reviews major achievements of applying traditional Chinese medicine for the treatment of stroke as well as the understanding and development of Chinese medicine on Hyperlipidaemia. Then, the paper sums up and analyzes modern research progress of the principles and methods of Western treatment and Chinese medicine treatment. With the summary of previous studies of Chinese medicine on regulate grease treatment and syndrome, the paper proposes to apply modern research design and statistical methods for the development of relevant studies on Chinese medicine "syndrome" with abnormal blood lipid. The paper advocates the establishment of objective, standardized and uniform syndrome diagnostic criteria, which is considered as an important way for the establishment of standardized Chinese medicine for the preventive treatment of stroke.Research Objects and Methodology:This study is a retrospective case survey and case-control study. The research objects are selected as consecutive hospitalized patients with acute ischemic stroke from March 2005 to December 2008 in the Neurology Department of Conghua Traditional Chinese Medicine Hospital. It includes a total of 255 cases. According to whether the case is associated with essential hyperlipidemia, patients are divided into 125 cases in hyperlipidemia group, and the other 130 patients in the non-hyperlipidemia group. The paper is in compliance with the methods and principles of clinical epidemiology, and applies factor analysis to study the distributing rules of syndromes of traditional Chinese medicine of essential hyperlipidemia in ischemic stroke population. The SPSS 10.0 statistical software is applied for for statistical analysis.Research Result:With the application of factor analysis and calculation of factor scores, the paper obtains the syndrome combination of hyperlipidemia group and non-hyperlipidemia group as well as the syndrome distributing situation of each category. For hyperlipidemia group, five TCM syndromes are:spleen deficiency generating phlegm (48.80%), qi asthenia causing blood stasis (20.00%), liver Yang rising (14.40%), fire excess from yin deficiency (6.40%), and endogenous heat leading to intestines constipation (10.40%). For non-hyperlipidemia group, six TCM syndromes are:spleen deficiency generating phlegm (10.00%), qi asthenia causing blood stasis (14.62%), liver Yang rising (29.23%), fire excess from yin deficiency (23.08%), and endogenous heat leading to intestines constipation (11.54%), as well as phlegm excess generating exuberance of interior organs (11.54%). From the contrast of two syndrome groups, it can be seen that distribution ratio of syndrome types between two groups is quite different. Spleen deficiency generating phlegm of hyperlipidemia patients is much more significant than that of non-hyperlipidemia patients, while quasi spleen deficiency generating phlegm is a syndrome type with more specificity in hyperlipidemia group.Conclusion:1. Quasi spleen deficiency generating phlegm, qi asthenia causing blood stasis, hyperactivity of yang due to yin deficiency are major symptoms of essential hyperlipidemia in ischemic stroke patients, among which, Spleen Qi deficiency and turbid phlegm obstructing the lung are the main pathogenesis.2. This research studies on the distributing rules of syndromes of traditional Chinese medicine of essential hyperlipidemia in ischemic stroke population, obtaining the distribution and characteristics of the clinical syndromes. The research provides of clinically guiding significance for the studies on TCM preventive treatment of risk factors for ischemic stroke.