Studies On The Constituents From Root Bark Of Celatrus Angulatus

Celastrus Angulatus belongs to the genus Celastrus. Such genus plants are widely distributed in the mountain area along the Yangtze river and the yellow river valley of China. This genus is a traditional insecticidal plant. Its root bark mostly has the effect on controlling some kinds of vegetable pests. In order to make further use of the Chinese herbal resources and find active compounds, we have undertaken a systematic investigation on the chemical constituents of the root bark of Celastrus Angulatus.17 compounds were isolated from the ethanolic extracts of the root bark of Celastrus Angulatus by using a variety of isolation methods and technologies. And 15 of them were identified by using various modern spectrometric approaches, including 1H-NMR, 13C-NMR, EI-MS, 1H-1H COSY, HSQC, HMBC, NOESY etc. They were:β-sitosterol(G-01),1β,2β-diacetoxy-8α,13-diisobutanoyloxy-9β-benzoyloxy-4α,6α-di hydroxy-β–dihydroagarofuran(G-02),1β,2β,6α-triacetoxy-8β,13-diisobutanoyloxy-9α-benzoyloxy-4α-hydroxy-β–dihydroagarofuran(G-03),1β,2β,6α-triacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-13-(α-methyl)-butanoyloxy-4α-hydroxy-β-dihydroagarofuran(G-04),1β-picolinoyloxy-2β,6α-diacetoxy-8β,13-diisobutanoyloxy-9α-furanoyloxy-4α-hydroxy-β–dihydroagarofuran(G-05),1β-picolinoyloxy-2β,6α-diacetoxy-8β,13-diisobutanoyloxy-9α-benzoyloxy-4α-hydroxy-β–dihydroagarofuran(G-06),1β,6α-diacetoxy-2β-nicotinoyloxy-8β,13-diisobutanoyloxy-9α-benzoyloxy-4α-hydroxy-β–dihydroagarofuran(G-07),1β,2β,6α-triacetoxy-8β,13-di(α-methyl)-butanoyloxy-9α-benzoyloxy-4α-hydroxy-β–dihydroagarofuran(G-08),quercetin(G-09),catechin(G-10),epicatechin(G-11),β-daucosterol(G-12),isoquercitrin(G-13),m-dihydroxybenzene(G-14),dulcitol(G-15). Three of them, G-05,G-06,G-07 are new compounds. G-08 was isolated from such plant for the first time.