Study On The Corelationship Between Resistin And P-selectin Levels In Patients With Acute Coronary Syndrom

ObjectiveTo investigate the changes of plasma resistin and P-selectin levels and study on the corelationship between resistin level and P-selectin level in patients with acute coronary syndrome(ACS). Methods102 patients with ACS were proved by coronary angiograph, including 50 acute myocardial infarction(AMI) cases and 52 unstable angina Pectoris(UAP)cases,40 patients with dubious coronary heart disease (CHD) but proved by coronary angiograph to be normal were selected as control cases. The method of ELISA was used to determine the plasma resistin and P-selectin levels. total cholesterol (TC), triglycerides(TG) were investigated by enzyme reagent method, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were investigated by direct method in the unified test center of the second hospital of Shanxi medical university.Results1.The plasma resistin level in ACS group was significantly higher than that in control group[(4.09±0.78)ng/ml vs (3.17±0.35)ng/ml P<0.05J and the plasma resistin level in AMI group was significantly higher than that in UAP group[(4.49±0.76)ng/ml vs (3.70±0.59)ng/ml P＜0.05].2.The plasma P-selectin level in ACS patients was significantly higher than that in control group [(129.97±6.72)ng/ml vs (80.42±4.75)ng/ml P＜0.05] and the plasma P-selectin level in AMI group was significantly higher than that in UAP group[(133.77±6.55)ng/ml vs (126.31±4.56)ng/ml P<0.05].3.The plasma resistin level was positively correlated with TG(r=0.28 P<0.05),negatively correlated with HDL(r=-0.45 P<0.05).4.The plasma resistin level was positively correlated with P-selectin(r=0.43 P<0.05).ConclusionLACS patients have increased plasma resistin levels. plasma resistin levels was significantly higher in AMI group than in UAP group.suggesting that resistin in the occurrence and development of ACS has played an important role.2.ACS patients have increased plasma P-selectin levels, suggesting that endothelial cell dysfunction and platelet high activity state. P-selectin in AMI group was significantly higher than UAP group which indicates that AMI patients may have heavier degree of platelet activation than that in UAP patients.3.plasma resistin levels was positively correlated with TG,and HDL were negatively correlated, suggesting that the resistin involved in CHD by causing the development of dyslipidemia.4.plasma resistin levels in patients with ACS was positively correlated with P-selectin, suggesting that plasma resistin levels increased with P-selectin levels in patients with ACS, both common may play a role in the occurrence and development of ACS.