Correlative Study On Plasma Levels Of Resistin In Patients With Acute Coronary Syndrome And Its Factors

Objective: To detect plasma resistin levels in patients with acute coronarysyndrome （ACS） and the normal control patients. To study the different levels ofplasma resistin in patients with unstable angina (UA) and the patients with acutemyocardial infarction (AMI). To analyze the relation between resistin and hypertension.To observe the correlation between resistin and age, smoking, height, weight, bodymass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, totalcholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C),high-density lipoprotein-cholesterol （HDL-C)，fasting blood glucose (FBG), bloodpressure (BP), white blood cell (WBC), creatinekinase (CK),creatinekinase-MB(CK-MB), troponin I (Tpn-I).Methods: It is a case-control study.75patients (46males, mean age59.30±11.11years;29females, mean age64.93±8.76years) with chest pain or chestdistress were enrolled in the study. All patients with coronary angiograph were dividedinto AMI group and normal control group. The ACS patients with>50%stensis in oneor more than one of the four coronary arteries (left coronary artery, right coronary artery,circumflex coronary artery, anterior interventricular artery) supplying the myocardiumconfirmed on coronary angiography. The25normal control patients (10cases withhypertension) with on stenosis in coronary arteries confirmed on coronary angiography.According to clinical symptoms, changes in laboratory results and electrocardiogram，the patients of ACS group (50cases,30cases with hypertension) were divided into UAgroup (25cases,14cases with hypertension) and AMI group (25cases,16cases withhypertension). The plasma resistin levels were examined in enzyme-linkedimmunosorbent assay （ELISA）. The blood lipid, fasting blood glucose, white bloodcell, CK, CK-MB, Tpn-I were measured at the same time. Results:(1) The plasma resistin level in ACS group (51.7±8.49ng/ml) washigher than that in normal control group (44.68±6.89ng/ml, P<0.01). The plasmaresistin level in AMI group (54.17±8.57ng/ml) was higher than that in UA group(49.23±7.81ng/ml, P<0.05).(2) There was no difference in plasma resistin between thenomal control group with hypertension (45.64±5.7ng/ml) and the normal control groupwithout hypertension (44.04±7.7ng/ml, P>0.05). There was no difference in plasmaresistin between the ACS group with hypertension (52.09±9.22ng/ml) and the ACSgroup without hypertension (51.12±7.45ng/ml, P>0.05). There was no difference inplasma resistin between the AMI group with hypertension (55.14±8.28ng/ml) and theAMI group without hypertension (52.43±9.35ng/ml, P>0.05). There was no differencein plasma resistin between the UA group with hypertension (50.04±5.72ng/ml) and theUA group without hypertension (48.6±9.3ng/ml, P>0.05).(3) Multiple linear regressionanalysis demonstrated that the plasma resistin levels were positively correlated withCK-MB and Tpn-I.Conclusion:(1) The plasma resistin level in ACS group was higher than that innormal control group. The plasma resistin level in ACS group was higher than that inUA group.(2) There was no correlation between hypertension and the plasma resistin.(3) The plasma resistin levels were closely related with myocardial injury, the moreseverely myocardial injury, the higher plasma resistin levels. Plasma resistin level maybe a marker of myocardial injury in ACS patients.