Expression And Its Significance Of Aquaporin 5 In Nasal Polyps With Or Without Allergic Rhinitis

ObjectiveAquaporins (AQPs) is a kind of membranous protein found odd-come-shortly,which play an important part in the liquid transfer and some secretory function. So far, a lot of research only studied between AQPs and sub-airway mucosa. There is few paper about the relationship between AQPs and up-airway mucosa's edema and secretory function, special the nasal mucosa.Our research confirmed the expression and distribution of AQP5 in the two kinds of nasal polyps by immunochemistry. It is to discuss the pathology function of the AQP5 in nasal polyps.MethodsChoose from these inpatients who came into our department to receive nasal polyps resection. AQP5 were studied in 20 samples nasal polyps without AR (Group NAR) and 16 samples with AR (Group AR) with immunochemistric staing, by its integrated light intensity and its grey step.Results1,The grey step of AQP5 in the cells of FP-using group is lower obviously than using FP before(p<0.05),the light intensity is higher obviously than using FP before(P<0.05).2,immunohistochemical staining technique showed that the distribution of AQP5 in the two groups was in accordance with that in nasal polyps on the whole. AQP5 expressed mainly in the glandular cells,lymphocytes,epithelial cells and inflamnatory cells.3,In the nasal polyps of FP-using group,the size of nasal polyps become much smaller than using FP before.The grey step of AQP5 in both glandular cells and lymphocyte is higher obviously than using FP before(P<0.05) but the light intensity is lower obviously than using FP before(P<0.05).Conclusionsthe expressions of AQP5 in cells which treated with FP became higher than cells which untreated,It indicated that when treated with FP,interstitial fluid can effuse easily,the concha nasalis media and the concha nasalis inferior became smaller and smaller. After nasal polyps samples treated with FP,the poloyps became smaller.At the same time,the expressions of AQP5 in glandular cells and lymphocyte became lower .There may be relationship between these.It can indicate that AQP5 contributed to edema of nasal polyps.