Clinical Observation Of LASEK On Moderate Myopia Correction With Mitomycin C

Objective: To evaluate the feasibility of mitomycin c (MMC) in preventing Haze and the stability of visual functional state after laser epithelial keratomileusis (LASEK ) surgery of moderate myopia.Methods: The study was taken in 36 eyes of moderate myopia patients received LASEK. Eyes were divided into 19 eyes of conventional LASEK (control group) and 17 eyes of 0.02%MMC+LASEK (MMC group). Observe and compare the postoperative pain score, recovery time of corneal epithelium, Haze and the stability of the recovery of visual outcomes, such as uncorrected visual acuity (UCVA), contrast sensitivity function (CSF) and stereoacuity.Results: The UCVA of all eyes improved over time. In the 1st month, 3rd month and 6th month after operation, the percentage of eyes which reached UCVA 1.0 in MMC group were 12(63.16%), 15(78.95%), 19(100%) and in control group were 11(64.71%), 14(82.35%), 17(100%). The UCVA between two groups in the 1st week, 2nd week,1st month, 3rd month and 6th month was no significant difference, p>0.05. All eyes in two groups got 1 score or below except one eye got 3 score in control group, postoperative corneal irritation score was no significant difference between two groups, p>0.05. All eyes healed within 1w after operation in two groups except one eye's epithelium flap was uncovered last 14 days in control group, recovery time of corneal epithelium was no significant difference between two groups, p>0.05. within the six month, the number of eyes suffered Haze level 0.5 in MMC group in the 1st month, 3rd month and 6th month after operation was 2,7,1 and control group was 8,8,2. P value was 0.025, 0.736, 0.593, Haze rate was significant difference (p<0.05) between two groups in 1st month after operation. Haze in MMC group is lighter than control group. Haze rate in 1 grade was no significant difference between two groups, p>0.05. The value of CSF in two groups was declined in 1st month but in 3rd month reached the level when attained preoperative. Both the value of CSF and stereoscopic vision showed no significant difference between two groups, p>0.05.Conclusion: LASEK with 0.02% MMC is more effective than conventional LASEK in preventing postoperative Haze for moderate myopia, and shows no significant postoperative pain, recovery time of corneal epithelium. However, LASEK with 0.02% MMC appears to be equally effective than conventional LASEK in postoperative UCVA, CSF and stereoscopic vision.