| Objective:To access the renal perfusion in patients with liver cirrhosis at different levels by contrast-enhanced ultrasound with time-intensity curve and investigate relationships between the parameters of the time intensity curve and degrees of patients with liver cirrhosis, for the detection of abnormalities of renal perfusion to provide basis for clinic.Methods:Thirty-one patients with liver cirrhosis were divided into:thirteen compensated cirrhosis group and eighteen decompensated cirrhosis group; thirty normal controls. Child-pugh scores were calculated for all the patients of hepatocirrhosis. Maximal long-axis cross-section image of renal was acquired by 2D ultrasound and then contrast-enhanced ultrasound (MI=0.07) was performed on right kidney. Renal perfusion was analyzed quantitatively with the time-intensity curve by QontraXt software. The parameters of the time intensity curve include peak signal intensity (Peak), time to peak intensity (TP), sharpness and area under the curve (AUC), ratio of peak intensity (RP). Investigate the changes of renal perfusion and time-intensity curve parameters in hepatocirrhosis at different levels. The relationships between parameters and child-pugh scores of patients with liver cirrhosis were studied.Results:â‘ Compared with the normal group, peak signal intensity and ratio of peak intensity decreased in the compensated cirrhosis group (P<0.05), time to peak delayed in compensated cirrhosis group, but it showed no statistical significance (P>0.05), peak signal intensity and ratio of peak intensity decreased in decompensated cirrhosis group (P<0.01), time to peak delayed significantly and were statistically significant (P<0.01). Compared with the compensated cirrhosis group, peak intensity decreased in the decompensated cirrhosis group (P<0.01), ratio of peak intensity decreased in the decompensated cirrhosis group (P<0.05).Sharpness and area under the curve showed no statistical significance in the three groups (P>0.05).â‘¡Peak signal intensity and ratio of peak intensity showed a significant correlation with the Child-Pugh score (P<0.01, P<0.05). Time to peak, sharpness and area under the curve showed no correlation with the Child-Pugh score (P>0.05).Conclusions:Contrast-enhanced ultrasound combined with time-intensity curve can analyze renal perfusion of hepatocirrhosis quantitatively at different stages. Peak signal intensity and ratio of peak intensity closely related to the degree of cirrhosis, which are good parameters for renal perfusion in hepatocirrhosis.
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