Correlation Research Of MVD,VEGF And Sel-P In Colorectal Cancer

Background Colorectal cancer is one of the most common gastrointestinal cancer. In recent 20 years, with the improvement of living standards, the gradual Westernization of diet and environment changes, the incidence of colorectal cancer was significantly increased. Tumor angiogenesis is the basis for the survival and development of tumor. VEGF is the strongest angiogenesis promoting factor. Sel-P has the antitumor effect. It has great significance for the early diagnosis and treatment of colorectal cancer to deeply study the interaction of VEGF, Sel-P and MVD in the occurrence and development of colorectal cancer.Objective To study the expression of VEGF and Sel-P in colorectal cancer, colorectal adenomas and normal colon tissues and the interaction in tumor angiogenesis and relationships of their colorectal cancer, probing their effects on the occurrence and development of colorectal cancer.Methods Colorectal cancer (65cases), colorectal adenomas (17cases) and normal colorectal tissues (12cases) specimens were collected by endoscopic at Heji Hospital of Changzhi Medical college from July 2009 to January 2011. Detecting the expression of VEGF, Sel-P and MVD with method of SP. Statistical analysis applications for statistical package SPSS 13.0:the Kruskal-Wallis H test, ANOVA, Spearman rank correlation analysis, P<0.05 statistically significance.Results The expression of MVD in colorectal cancer and normal colorectal tissue, colorectal adenoma and normal colorectal tissue, colorectal cancer and colorectal adenomas, group differences were significant (t=6.736,p=0.000;t=2.428,p=0.017;t=4.409,p=0.000).The expression of VEGF in colorectal cancer and normal colorectal tissue, colorectal adenoma and normal colorectal tissue, colorectal cancer and colorectal adenomas, group differences were significant (t=4.321,p=0.000;t=2.000,p=0.048;t=2.216, p=0.029).Sel-P expression in colorectal cancer and normal colorectal tissue,colorectal adenoma and normal colorectal tissue, colorectal cancer and colorectal adenomas, group differences were significant (t=4.571,p 0.000;t=2.250,p=0.027; t=2.158,p=0.034).VEGF and MVD expression in colorectal cancer was a significant positive correlation (rs=0.702 p=0.000), Sel-P and MVD, VEGF and Sel-P expression in colorectal cancer showed a significant negative correlation (rs=-0.371 p=0.002; rs=-0.263 p=0.035).Conclusionsâ‘ MVD count marked by CD34 in colorectal cancer was significantly higher than that of colorectal adenoma and normal colon tissue, and was statistically significant, suggesting that angiogenesis plays a facilitating role in the occurrence and development of colorectal cancer.â‘¡Compared with normal colon tissue and colorectal adenoma, VEGF was highly expressed and Sel-P was lower in colorectal cancer,and were statistically significant, suggesting that VEGF was a promoting factor of colorectal cancer, Sel-P was a protective factor of colorectal cancer.â‘¢In colorectal cancer the expression of VEGF and MVD were significantly positively correlated, Sel-P and MVD was significantly negatively correlated, Sel-P and VEGF was negatively correlated, suggesting VEGF can promote angiogenesis, Sel-P may inhibit angiogenesis, Sel-P may inhibit the expression of VEGF, Their interactions played an important role in the occurrence and development of colorectal cancer. Combined detection of the expression of MVD, VEGF and Sel-P provided important theoretical basis in clinical evaluation for the incidence, development, treatment and prognosis of colorectal cancer.