Study On Distribution Of TCM Syndrome Types And Its Relationship With The Quantification Of HBV DNA And Immunological Indices In Chronic Hepatitis B Virus Carriers

Object i vesTo investigate the distribution characteristics of Traditional Chinese Medicine (TCM) syndrome types in chronic hepatitis B virus carriers and research the correlation between syndrome types and quantification of HBV DNA,Immunological Indices.MethodsClinical epidemiological investigation was adopted. The basic information,clinical symptoms and some lab examination results such as quantification of HBV DNA,Immunological Indices in 215 chronic hepatitis B virus carriers were collected.All indexes were input into the database and were unscrambled.Data were analyzed by SPSS 16.0 version statistic software. Description of frequency was used to sum up the distribution characteristics of TCM syndrome types. Chi-square test was used to compare the rate, and ANOVA or t-test was used to compare the mean.Test level was a=0.05. Thus the distribution characteristics of TCM syndrome types in chronic hepatitis B virus carriers and the correlation between syndrome types and examination results were analyzed scientifically.Result1. The proportions of TCM syndrome types in 215 patients included the survey were:stagnation of liver-qi and spleen deficiency>dampness-heat accumulation >yin deficiency of liver and kidney>damp abundance due to splenic asthenia >yang deficiency of spleen and kidney>obstruction of collaterals by blood stasis. Which, the proportions of TCM syndrome types in HBeAg-positive patients were:stagnation of liver-qi and spleen deficiency=dampness-heat accumulation > yin deficiency of liver and kidney> damp abundance due to splenic asthenia > yang deficiency of spleen and kidney=obstruction of collaterals by blood stasis; the proportions of TCM syndrome types in HBeAg-negative patients were: stagnation of liver-qi and spleen deficiency>yin deficiency of liver and kidney>dampness-heat accumulation>damp abundance due to splenic asthenia >yang deficiency of spleen and kidney>obstruction of collaterals by blood stasis.2. The relationships between TCM syndrome types and quantification of HBV DNA were:when the range of quantification of HBV DNA below 5.0×102 copies/ml and within 5.0X102copies/ml to 104copies/ml, the frequency of dampness-heat accumulation syndrome was less than other syndromes; when the range of quantification of HBV DNA within 104 copies/ml to 106 copies/ml and above 106 copies/ml, the frequency of dampness-heat accumulation syndrome was more than other syndromes, and there was no difference among the others. It suggested that patients with dampness-heat accumulation syndrome were more prone to the situation that viral replication was active than patients with other syndromes.3. The relationships between TCM syndrome types and immunological indices were:(1)The relationships between TCM syndrome types and quantification of T lymphocyte subsets were:the quantification of CD4+ within dampness-heat accumulation syndrome was lower than that within other syndromes, and the patients with dampness-heat accumulation syndrome were more prone to the situation that the quantification of CD4+ was below the normal range than the patients with other syndromes; the CD4+/CD8+ within dampness-heat accumulation syndrome was lower than that within stagnation of liver-qi and spleen deficiency syndrome,yin deficiency of liver and kidney syndrome,damp abundance due to splenic asthenia syndrome.(2)The relationships between TCM syndrome types and quantification of immunoglobulin were:the quantification of IgG within dampness-heat accumulation syndrome was significantly higher than that within other syndromes, and the patients with dampness-heat accumulation syndrome were more prone to the situation that the quantification of IgG was above the normal range than the patients with other syndromes; the quantification of IgA within obstruction of collaterals by blood stasis syndrome was lower than that within stagnation of liver-qi and spleen deficiency syndrome,dampness-heat accumulation syndrome,yin deficiency of liver and kidney syndrome.(3)The relationships between TCM syndrome types and quantification of complement were:the quant if ication of C3 within dampness-heat accumulation syndrome was lower than that within other syndromes, and the patients with dampness-heat accumulation syndrome were more prone to the situation that the quantification of C3 was below the normal range than the patients with other syndromes; the quantification of C4 within yin deficiency of liver and kidney syndrome was lower than that within other syndromes, and the patients with yin deficiency of liver and kidney syndrome were more prone to the situation that the quantification of C4 was below the normal range than the patients with other syndromes; the quantification of CH50 within damp abundance due to splenic asthenia syndrome was lower than that within other syndromes, and the patients with damp abundance due to splenic asthenia syndrome were more prone to the situation that the quantification of CH50 was below the normal range than the patients with other syndromes.4. The comparisons in immunological indices between HBeAg-positive patients and HBeAg-negative patients were:(1)The quantification of CD4+ and CD4+/CD8+ in HBeAg-positive patients were lower than that in HBeAg-negative patients, and the quantification of CD8+ in HBeAg-positive patients were higher than that in HBeAg-negative patients, but there was no significant difference between the quantification of T lymphocyte subsets in HBeAg-positive patients and that in HBeAg-negative patients.(2)There was no significant difference between the quantification of immunoglobulin and complement in HBeAg-positive patients and that in HBeAg-negative patients.ConelusionThe distribution of TCM syndrome types in chronic hepatitis B virus carriers has its characteristics. There is some relationship between TCM syndrome types and the quantification of HBV DNA,immunological indices.