The Research On Inhibitory Effects Of Pyridoxamine On Arteriosclerosis

Objective To observe the effect of pyridoxamine On arteriosclerosis formation and its potential mechanism.Methods The atherosclerosis model with rabbits was established with high fat diet. male New Zealand white rabbits were randomly divided into 4 groups: normal control group,atherosclerosis model group,pyridoxamine group 1(100mg/kg.d),pyridoxamine group 2(150mg/kg.d). PM1 and PM2 groups were treated with corresponding drugs or diet for 12 weeks . Blood glucose and serum lipids levels were measured on the 12th weeks. serum advanced glycosylation end-products levels were measured with ELISA method. Aortae were analyzed by histopathological examination.The expression of RAGE in rabbits'aortae tissue slices was measured by immunohistochemistry.Results (1) Compared with those in NC group,TG,CHOL,LDL-C,HDL-C,contents of AGEs,RAGE and Plaque proportion increased significantly(P<0.05)in AS group, but the differences of blood glucose were not significant(P>0.05). (2) Compared with those in AS group, contents of AGEs,RAGE and Plaque proportion decreased significantly(P<0.05)in PM1 and PM2 groups, but TG,CHOL,LDL-C,HDL-C and BG were not significant(P>0.05). (3) Compared with those in PM1 group , contents of AGEs,RAGE and Plaque proportion decreased significantly (P<0.05) in PM2 groups.Conclusion pyridoxamine may be contribute to the anti-atherosclerosis in Rabbits with AS. It has a certain role in preventing vas damnification by alleviating the accumulation of advanced glycosylation end-products and RAGE.