Investigate The Inflammatory Marker And Coagulation Factors And The Allele Frequencies Of The CRPG1059C In Pulmonary Thromboembolism

Objective:TO detect the allele frequencies of the CRPG1059C Polymorphism and Whether serum high-sensitivity C-reactive protein, D-dimer and coagulation factorⅦlevels and the Prevalent Pulmonaryembolism diseases are associated with PTE. Methods: The patients with Pulmonaryembolism undergoing selective venous ultrasonography were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism was used for the screen CRPG1059C polymorphism in exon of C-reactive protein gene in 213 cases and 213healthy control subjects, the frequency of mutation was counted. The plasma levels of high-sensitivity C-reactive and coagulation factorⅦlevels protein levels were detected by ELESA in 164 cases and 82 healthy control subjects, and the serm leveles of DD were detected by immunoturbi-dimetry in 164 cases and 82 healthy control subjects. Results:The mean levels of plasma high-sensitivity C-reactive protein levels was significantly higher in pulmonaryembolism than that in controls [Hs-CRP, (35.79±3.12) vs (10.03±1.25) (pg/ml)], it showed significant difference (P< 0.05), and the serm levels of DD was significantly higher in Pulmonaryembolism than that in controls [DD, (1359.47±337.04) g/L vs (360.00±90.5)]. The serm levels of FⅦa was significantly higher in Pulmonaryembolism than that in controls [FVⅦa, (209.80±87.89)pg/ml vs (71.27±26.83) pg/ml] The frequence of GG was 88.8% and 86.4% in 213 cases and 213 healthy control subjects, the frequence of GC was 7.5% and 10.3%,and CC 3.7%and 3.3%.The frequencies of G and C alleles in CRPG1059C were 91.5% and 8.5%. Multiple logistic regression analysis showed diabetes mellitus,DM history of lower extremity venous and PTE, WBC, FIB,Hs-CRP,DD,FⅦa were independent risk of PTE. The date also confirmed that Hs-CRP,DD and FⅦhave a higher risk of PTE. Conclusions:Inflammation reactions involved in the pulmonary embolism have pathological process. In the PTE pathological process, blood in high condensation and fibrinolytic hyperfunction condition, and exogenous clotting mechanism may be involved in the pulmonary embolism form the pathological process. The polymorphisms of CRP1059G/C was not significantly associated with the risk of PTE in this study population.