| Atherosclerosis Obliterans is a disease caused by atherosclerosis, a common peripheral vascular disease, belongs to Chinese medicine, "tuoju" "maibi" and other areas. Maifusheng is a herbal preparation that have been used for over 40 years in TCM Hospital of Guangzhou for the treatment of peripheral vascular disease, and achieved good effect. It has the advantage of safe, reliable and easy_to_time taking.ASO diverse etiology, pathogenesis is very complex. Ross in 1999, based on the theory of endothelial injury in response to clearly stated, AS is an inflammatory disease, this view has been gradually accepted by people. Many data indicate that dyslipidemia can lead to vascular endothelial cell injury, inflammatory cells can release large amounts of inflammatory mediators, and promote the development of ASO. ObjectiveA revival of past research on the Maifusheng is limited to the therapeutic aspect of thromboangiitis oblitetans studies and animal experiments to study the aspects of AS of vascular endothelial cells. This study is intend to have the clinical research to take the systemtic observation of patients and efficacy assessment of the Maifusheng's treatment for ASO Phase I, Phase II, grade one and grade two level of Phase III. Patients were observed on lipid metabolism and CRP, IL-6, TNF-a, ICAM-1. Comprehensive analysis and evaluate its clinical efficacy, based on the lipid and cytokines levels to observe the Maifusheng decoction's aspects of the efficacy and role mechanism in the regulation of lipid metabolism, reduce CRP AND other inflammatory factors, and inhibition of monocyte adhesion to vascular endothelial cells. MethodsSelect our department in March 2010 to January 2011 hospitalized patients of ASO total of 90 cases. Randomized controlled according to the principles of randomized controlled table divided into treatment group and control group,45 patients in each group.15 days for a course of treatment for a period of 30 days of treatment. Two groups of patients who have the wound will be treated by Shengjigao cream, removal lf necrotic tissue and gradually erode law. Control group received routine antibiotics, control of blood pressure, blood glucose, coagulation, improve circulation, support treatment and other basic medical treatment. The treatment group plus Maifusheng to the basis of the oral treatment, twice daily 50ml. Observed before and after treatment in patients with symptoms and signs lf change itself, and before and after treatment with Doppler measurement of ankle/brachial index, and blood taken of rheology, comprehensive comparison of the efficacy difference between the two groups. In the peripheral blood serum lipids(CHOL, TG, LDL,HDL) levels and CRP, IL-6, TNF-a,ICAM-1 were compared before and after the change and its difference between the two groups.Result1 Maifusheng can improve blood rheology, increase ankle/brachial index and improve clinical symptoms and signs. After treatment, the efficiency of pulse resuscitation treatment group were 56.56%,97.78% total efficiency. Compared with the control group, control group was 40%, total effective rate 86.67%, the statistical treatment, there was significant difference between the two groups (P<0.05), that the treatment group significantly better than the control group.Before and after treatment, patients in the intermittent Postscript symptom score line, limb pain, numbness, limb skin color, limb skin temperature in the treatment group compared with the control group significantly improved (P<0.05); the treatment group compared to patients in five symptoms also were significantly improved compared with before treatment (P<0.01). ABI values after treatment, blood rheology, between the two groups, the treatment group were significantly better than the control group (P<0.01, P<0.05); group compared with the treatment group after treatment than before treatment also significantly better(P<0.01). 2 Maifusheng can reduce blood lipid levels and CRP, IL-6 TNF-a, ICAM-1 levels. ASO in reducing serum total cholesterol, triglyceride, low density lipoprotein, In the treatment group before and after treatment were significantly different (P<0.05); treatment group and control group blood lipids, plasma lipoproteins of the indicators were significantly different (P<0.05), but HDL (P= 0,878> 0.05), no significant statistical difference, no significant increase of the role of HDL.Within the treatment group before and after treatment CRP, IL-6, TNF-a, ICAM-1 were significantly different (P<0.01, P<0.05); After treatment, the treatment group and control group CRP, IL-6, TNF-a, ICAM-1 were significantly different(P<0.05),the treatment group is better than the control group.ConclusionMaifusheng has a good effect in regulation of lipid metabolism, reduce CRP and other inflammatory factors, anti-arterial inflammation, and inhibition of monocyte adhesion to vascular endothelial cells. It can inhibit the development of arteriosclerosisobliterans, has better therapeutic effect to ASO. |
PDF Full Text Request