The Clinical Study Of Medication In Deep Venous Thrombosis

Object:Through investigating the effects of the different protocols for treatment of DVT, which basing on disease suffering time and application of thrombolysis or not, to provide the theoretical basis for clinical treatment for DVT.Method: The clinic data of 379 patients of DVT treated in our departments from 2006 to 2010 were reviewed. Totally 379 DVT cases who received medication therapy were enrolled, and were divided into three groups: acute stage(≤3days), subacute stage(3～14days) and chronic stage(>14days) group according to diseased time. Each group were more divided into two sub-groups according to therapeutic schedule: thrombolysis plus anti- coagulation and anticoagulation alone. Changes of the lower extremity circumference and variation of coagulation indexes were recorded in each group to measure the therapeutic effect. All data were treated with SPSS(12.0) statistical package.Result: 379 cases with DVT were reviewed, and the patients in acute stage has best curative effect; the clinical efficacy in thrombolysis plus anticoagulation subgroup has better outcome than in anticoagulation alone subgroup (P<0.01), but no significant difference(P>0.05)in variation of coagulation indexes and complication rate among the subgroups. The date of 158 patients with postoperative thrombosis of deep venous in lower extremities treated by medication therapy were analyzed retrospectively: the curative and obvious effective rate was 73% in thrombolysis plus anticoagulation group, respectively. In the anticoagulation alone group the curative and obvious effective rate was 42% and there were significant differences between the two groups (P<0.01), but no significant difference(P>0.05)in variation of coagulation indexes and complication rate among the two groups.Conlusions: Combined therapy with thrombolysis, anticoagulation , and anti-platelet Adhesion therapy is primary treatment of DVT. Thrombolysis plus anticoagulation and anti-platelet adhesion treatment were effective for patients in non-acute stage and it is an effective and safe method for postoperative DVT under the tight monitoring.