Clinical Study Of The Treatment Of PF With Matrine Injection

Objective:To observe the effect of matrine injection on the lung mesenchymal fibrosis patient's quality of life clinical smptoms and inflammatory factor.Methods:60 patients with lung mesenchymal fibrosisi were divided into two groups at random:the treatment group and the control group. The treatment group was given matrine injection,small amount of glucocorticoid and symptomatic treatment.The control group was small amount of glococorticoid and symptomatic treatment, 4 weeks were set as a course of treatment. The clinical effects of each group were observed during the course. Results:Clinical studies have shown that the treatment group,the quality of life in patients with pulmonary fibrosis, clinical symptoms and inflammatory factors were better than the control group. Treatment can significantly improve the quality of life of patients,improve breathing, coughing and other symptoms,serum levels of interleukin -4 (IL-4) levels were significantly decreased, the effective than the control group (P <0.05 or P <0.01).The two groups no adverse reactions during treatment.Conclusions:Matrine effective in the treatment of pulmonary fibrosis. The mechanism may be through inhibiting the expression of IL-4, thereby inhibiting the development of TH2 toTH0 reduce fibroblast proliferation and differentiation.