Comparative Study Of Treatment Effect Of Yang-Warming And Fluid-Dispersing Formula And Syndrome Of Decoction GAN CAO (Radix Glycyrrhizae) GAN JIANG(Rhizoma Ziniberis) In Treating Rat Model With Syndrome Of Accumulation Of Cold Fluid In The Lung In Chronic

Objective:In theory,chronic obstructive pulmonary disease Yun cold drink interpretation of the lung and demonstration of a system to enrich the theory of the lung Yun cold drink.By fumes,cold stimulation of tracheal instillation of LPS plus ways to establish chronic obstructive pulmonary disease Yun cold drink rat model of the lung.Meanwhile,the observed warming yang side of the drink,dry ginger and licorice budesonide on chronic obstructive pulmonary disease,the lung model of cold drink Yun intervention effects,and to evaluate differences in its efficacy for disease prevention and control permits for newideas and theories.Methods:The trial of COPD has been cold drink Yun-lung syndrome in rats model of the object,combined with chronic obstructive pulmonary disease pathogenesis,in the freezing winter cold environment in rats,rats give drinking ice water,together with the fume tracheal instillation of LPS used to establish chronic obstructive pulmonary disease pulmonary syndrome in rats Accumulation of Cold Fluid Model.With the yang side of the drink,dry ginger and licorice on the model rats budesonide intervention.The general situation in rats,histopathological changes,lung function test and serum on IL-8,IL-10.Results:Chronic obstructive pulmonary disease Yun cold drink rat model of the lung with cold drinks Yun general clinical manifestations of the lung consistent with changes in the indicators(except for serum IL-8 and IL-10 outside)also associated with chronic obstructive pulmonary disease consistent with changes in the indicators:weight loss in rats,increased inspiratory resistance and expiratory resistance,lung compliance,but elevated serum interleukin-8 and serum concentrations of interleukin-10 Compared with the normal group no significant change(P>0.05),lung biopsy revealed inflammatory injury occurred.Modeling factors in the removal of 4 weeks,chronic obstructive pulmonary disease Lung Yun cold drink in rats model of the indicators of general conditions and no significant improvement.With the yang side of the drink,dry ginger and licorice budesonide intervention improved symptoms of rats,lung function improved,the serum interleukin-8 and serum concentrations of interleukin-10 and chronic obstructive pulmonary disease Yun cold drink the lung compared with rats with no significant change(P>0.05),pathological examination showed significantly reduced inflammatory injury.Conclusion:The experimental methods to establish chronic obstructive pulmonary disease Yun cold drink rat model of the lung is feasible,there may be replicating their specific and stable.Yang side of the drink,dry ginger and licorice budesonide in chronic obstructive pulmonary disease Lung Yun cold drink in rats model of general,pulmonary function and inhibit airway inflammation have different degrees of positive effect,whichespecially yang side effects of drinking the most obvious,is better than dry ginger and licorice budesonide intervention effect,but this experiment can not yet dry ginger and licorice budesonide intervention differences assessed.