The Clinical Research About The Ginkgo Leaf Injection Cure Of The Tumor High Congealed State

The clinical research about the ginkgo leaf injection cure of the tumor high congealed stateObjective: In malignancy patients, the blood is usually in a thick, sticky, high viscosity state, malignancy patients are often complicated by bleeding, thrombus, and even disseminated intravascular coagulation (DIC). Coagulation- fibrinolysis abnormalities in tumor growth and proliferation play an important role. The mechanism is more complex, including procoagulant (tissue factor, cancer procoagulant material, etc.) and the release of cytokines, vascular endothelial injury. It is reported that cancer can not only activate the coagulation system, but also can lead to vascular endothelial cell damage and increase platelet activity, and abnormal fibrinolysis. Part of the study confirmed: Metastasis in tumor cells, the surface of tumor cells spreading in the blood vessels is a key process, clotting in this process plays an important role. According to Chinese medicine theory, combined with clinical tumor, TCM's "blood stasis" is similar to the characteristics of hypercoagulability. The dynamic process of thick, sticky, polyethylene and coagulation is a common pathological basis of both, throughout the whole tumorigenesis process and progress. So, to research the clinical relationship between the two has an important clinical significance from a practical point of view, and to find effective responses, to malignant thrombosis prevention and treatment, inhibit the progression and metastasis, improve the quality of life in patients, and prolong survival. Some research show: in patients with malignant plasma Fib, DD levels and PLT the parameters index changes associate with tumor metastasis, disease stages and prognosis. So the above can be used as indicators of coagulation status of patients with malignant blood coagulation observations. Ginkgo leaf has the effectiveness of promoting blood flow and relieve pain, releasing the clotting and getting through thesphygmo, indicating blood stasis. Large number of experimental studies and clinical research data shows that, Ginkgo leaf injection regulate metabolism, Eliminate the role of free radicals, etc. which can improve the blood rheology, Also can. Antagonism of platelet-activating factor,reduce blood viscosity and other pharmacological effects, so, Ginkgo leaf injection has an obvious effect on the improvement of hypercoagulability. But the clinical observation of the hypercoagulable state on the ginkgo leaf injection in cancer patients is reported fewer home and abroad. At present further research in this area has not yet started, many have yet to be discussed, especially the clinic remission rate of the tumor patients in chemotherapy hypercoagulability is not known.This study from the perspective of clinical laboratory, Study the reflection about the blood index to the tumor coagulation status. And from a clinical practical point of view, objectively reflect the coagulation status by drugs on the extent of mitigation, from the clinic practical angles, looking into the effection of ginkgo leaf injection on the hypercoagulable state of cancer. To achieve the control of the tumor incidence of thrombosis, inhibition of tumor progression and metastasis, in order to improve the quality of life in patients, and extend the lifetime of the purpose of cancer patients.Methods: Based on the data difference through the parameters index changes of the plasma Fib, DD levels and PLT, comparison of the observation group (conventional chemotherapy) and the experimental group 1 (conventional chemotherapy + ginkgo leaf injection treatment) and the experimental group 2 (conventional chemotherapy plus low molecular weight heparin treatment).To discuss the effect and safety of ginkgo leaf injection on patients with tumor hypercoagulability .Measurement data is expressed by the average plus±standard deviation ( x±s),the statistical is checked by the test of homogeneity of variance, t test, to judge the significant difference with P <0.05,Count data checked byχ~2, take P <0.05 for the significant difference.Result:1 Observer the observation group (conventional chemotherapy) and the experimental group 1 (conventional chemotherapy plus ginkgo leaf injection treatment) for the difference cure rate of the primary cancer.According to the clinical laboratory before and after treatment (tumor markers) and imaging studies show: in the conventional chemotherapy group, 50 patients, the condition improved and stable patients were 40 cases, Cases of 10 make much progress; Conventional chemotherapy with ginkgo leaf injection in the treatment group, 100 patients, the patients'condition improved and stable were 81 cases, 19 cases of disease progression;Comparing chemotherapy combined with ginkgo leaf injection in the observation group and the chemotherapy alone group, on aspects of the cancer treatment and outcome of the disease, there is no difference.Two sets of data show thatχ~2 = 0.0213, P > 0.05, the two groups have no statustucs difference. Conventional chemotherapy combined with ginkgo leaf injection treatment did not increase tumor progression and recurrence in patients, which shows the good security of ginkgo leaf injection to cure tumor patients.2 The effect of applying ginkgo leaf injection to cure tumor patients hypercoagulability.The observation group (conventional chemotherapy) and the experimental group 1 (conventional chemotherapy + ginkgo leaf injection treatment) before and after treatment , compare the count data of the plasma Fib, DD numerical control level and PLT , it shows: before treatment, two sets of data showed no significant difference, P>0.05; After treatment, the observation group (conventional chemotherapy of ginkgo leaf injection treatment) , the use of ginkgo leaf injection can decrease the count data of the plasma tumor Fib, DD levels and PLT in order to alleviate the tumor patient's blood hypercoagulability, P<0.05。3 Adverse reactions3.1 The experimental group 1 (conventional chemotherapy and ginkgo leaf injection therapy) 100 patients during the treatment, didn't occurre mucocutaneous blood spots, petechiae, gingival bleeding, melena clinical bleeding tendency, etc. During which 3 cases of skin allergy appeared, occurrence rate of 3%, and no other adverse reaction reports.3.2 The experimental group 2 (conventional chemotherapy plus low molecular weight heparin therapy) 50 patients, 10 cases of skin ecchymosis, occurrence rate of 20%, five cases of black just; occurrence rate of 10%;gingival bleeding occurred in 4 cases, occurrence rate of 8% ,in 50 patients.Some appear ecchymosed on the subcutaneous injection site, subcutaneous injection site induration and local pain, etc, so they required stopping the use of the low molecular weight heparin. For more than 10% of cancer patients withdrew before the completion of the second course of clinical research, the study had to be interrupted, so, the data before and after the treatment can't be checked.That case shows that ginkgo leaf injection has a good tolerability.4 The use of ginkgo leaf injection can decrease the cont of plasma Fib, DD levels and PLT, so as to achieve the remission in tumor patients with hypercoagulability. But for tumor patients of different ages, with or without angiogenesis, metastases or not, and the different metastatic sites, the application of Ginkgo leaf injection in regulating blood coagulation has the different effects.4.1 According to age group:In 65tumor patients under 60years old, after the application of ginkgo leaf injection , the count data of the plasma Fib, DD level and PLT decreased, prompting the treatment is effective in 52 cases; Monitoring indicators remained unchanged or increased in 13 cases. The efficiency: 80.0%In 35 tumor patients older than 60 years, the application of ginkgo leaf injection leads the count data of the plasma Fib, DD level and PLT to go down, prompting that the effective treatment is 14 patients; Monitoring indicators remained unchanged or increased in 21 cases. Efficient: 40.0%χ~2=16.22,P <0.05, there is a significant difference between the two groups.After the application of ginkgo leaf injection, the remission of hypercoagulable state has a more significant effect in the group younger than 60 than that older than 60.4.2 According to the gender divisionIn 48 cases of male tumor patients,after the application of Ginkgo leaf injection in the treatment , the count data of plasma Fib, DD numerical decline in the level and PLT decreased. Prompting the effective treatment of 39 patients; Monitoring indicators remained unchanged or increased in 9 cases. Efficient: 81.25%.In 52 cases of female tumor patients, after the application of Ginkgo leaf injection in the treatment, the count of plasma Fib, DD numerical decline in the level and PLT decreased, prompting the effective treatment of 40 cases; Monitoring indicators remained unchanged or increased in 12 cases. The efficiency: 76.92%.χ~2=0.28, P > 0.05 there was no significant difference between the two groups.Male and female tumor patients have no difference in the treatment.4.3 According to the results of immunohistochemistry, tumor patients were divided into non-angiogenesis group (25 cases) and angiogenesis group (75 cases).After the using of ginkgo leaf injection in no tumor angiogenesis patients (25 cases) the count data of plasma Fib, DD numerical decline in the level and PLT gets down.Prompting the treatment is effective in 18 cases; Monitoring indicators unchanged or increased in 7 cases. There is efficiency: 72.00%.A group of patients with tumor angiogenesis (75 cases) is applying the ginkgo leaf injection reduced the count data of the plasma Fib, DD numerical decline in the level and PLT. Prompting the effective treatment of 38 patients; Monitoring indicators remained unchanged or increased in 37 cases. There is efficiency: 50.67%.χ~2 =3.46,P value <0.05, there is no significant difference between the two groups.After applying the ginkgo leaf injection, the remission of hypercoagulability in no tumor angiogenesis were more significantly than angiogenesis. (Table 6)4.4 Under the CT and magnetic resonance (MRI) examination results, tumor patients were divided into two groups without metastasis (33 cases) and metastatic carcinoma (67 cases). According to the count data of plasma Fib, DD levels and PLT before and after the application of ginkgo leaf injection in the two groups. Before treatment, it showed no significant difference, P> 0.05, the observation group after treatment is compared with control group P <0.05.After the application of ginkgo leaf injection, the remission of hypercoagulability in non-metastasis carcinoma is more significantly than the metastasis carcinoma. ( table 7). 4.5 grouped according to the tumor metastatic sites: lymph node metastasis (37 cases), liver metastasis (19 cases) and bone metastasis (12 cases).Lymph node metastasis (37 cases), after the application of ginkgo leaf injection, the count data of the plasma Fib, DD numerical decline in the level and PLT decreased. Prompting the effective treatment in 29 cases; monitoring indicators remained unchanged or increased in 8 patients; the effective rate: 78.4%.Bone metastasis (12 cases) ,after the application of ginkgo leaf injection , the data of plasma Fib, DD numerical decline in the level and PLT decreased, prompting the effective treatment, 6 cases; monitoring indicators remained unchanged or increased in 6 cases; Effective rate of 50%.Liver metastasis (19 cases) , after the application of ginkgo leaf injection, the count data of plasma Fib, DD levels and PLT falls;Prompting treatment is effective in 8 cases; Monitoring indicators remained unchanged or increased in 11 cases; Effective rate of 42.1%.χ~2=7.49,P<0.01The difference between the remission rate was significant, after the application of ginkgo leaf injection treatment,the tumor response rate of the hypercoagulable state in a sequence is arranged in: Lymph node metastasis> bone metastasis group> liver metastasis. (Table 8)Conclusion:In this study, 100 cases of tumor patients on the therapy with Ginkgo leaf injection to improve and adjust the regulation of plasma Fib, DD levels and PLT count in order to relieve the hypercoagulability of tumor patients. This study by the way of clinical utility point of view, studies the relationship between blood parameters and the medication to seek an effective response, and to solve the tumor hypercoagulable state of the tumor patients。Control tumor thrombosis, inhibition of tumor growth and metastasis, cancer prevention and treatment of tumor patients and reduce complications and mortality in patients with extended survival time。Conclusions are as follows:1 Conventional chemotherapy combined with ginkgo leaf injection treatment did not increase tumor progression and recurrence in patients, suggesting that ginkgo leaf injection in a good security。2 The use of ginkgo leaf injection can decrease plasma Fib, DD levels and PLT count in order to alleviate the cancer patient's blood hypercoagulability.3 In the treatment, the group using ginkgo leaf injection were not occurring mucocutaneous blood spots, petechiae, gingival bleeding, Melina and other clinical bleeding tendency, skin allergies and other adverse reactions, which further confirmed the security of the ginkgo leaf injection in the treatment .4 Some of the tumor patients in the long-term anticoagulation therapy with low molecular weight heparin subcutaneous injection appear site ecchymosis ,subcutaneous injection site induration and local pain, etc., and they required to stop the drug, which caused more than 10% of the tumor patients to be out of the clinical research, therefore, the control group studies was interrupted. It also shows that Ginkgo leaf injection has a good tolerability.5 Although through the use of ginkgo leaf injection, it can regulate the plasma Fib, DD levels and PLT count of tumor patients can achieve remission hypercoagulability. For cancer patients of different ages, with or without metastatic cancer patients and cancer patients in different parts of the transfer, application of ginkgo leaf injection in regulating blood coagulation state has different effects.5.1 according to age groups: age <60 age group than cancer patients aged> 60 years old tumors were treated with ginkgo leaf injection in remission hypercoagulability significant effect.5.2 Grouped according to sex: male and female cancer patients have no difference in the treatment.5.3 The results of immunohistochemistry, patients were divided into non-tumor angiogenesis and angiogenesis groups. After application of ginkgo leaf injection, the remission rate of non-angiogenesis was significantly higher than angiogenesis.5.4 According to the result of CT and magnetic resonance imaging (MRI) examination , tumor patients are divided into two groups without metastasis and metastatic groups, after the application of ginkgo leaf injection, the remission rate of non-metastatic is significantly obverse than metastasis.5.5 grouped according to metastatic sites: lymph node metastasis, liver metastasis and bone metastasis. The difference between the remission rate was significant, the remission rate in a sequence was arranged as follows:: Lymph node metastasis> bone metastasis group> liver metastasis.