The Research Of Expression And Clinical Significance Of DcR3, HER-2/neu, KAI1 In Colorectal Cancer

Objective : This study aimed to investigate the expression of DcR3, HER-2/neu, KAI1 in colorectal cancer, and explore their relationship with colorectal cancer. Methods:IHC were used to investigate the expression of DcR3, HER-2/neu, KAI1 in the specimens of colorectal cancer and corresponding adjacent normal tissues. The correlations of DcR3, HER-2/neu, KAI1 to clinicopathologic features and prognosis of colorectal cancer were analyzed.Results:1. DcR3 expression in normal colorectal tissues was negative, but the positive rate in colorectal cancer was up to 58.33%. The expression rates of DcR3 were not related to sex, age, location, size of tumor and depth of infiltration. DcR3 expression in early colorectal cancer had a significant difference with that in advanced colorectal cancer (P<0.05). Tumor of patients with lymph node metastasis had significantly higher DcR3 expression levels than that without lymph node metastasis (P<0.05). It is as similar as lymph node metastasis when made a comparison between poorly differentiated group and well differentiated group in which DcR3 expression was lower (P<0.05).2. HER-2/neu/c-erbB-2 expression in normal colorectal tissues was negative, but the positive rate in colorectal cancer was up to 63.33%. The expression rates of HER-2/neu/c-erbB-2 were not related to sex, age, location, size of tumor but it had a inverse correlation with depth of infiltration, stage of TNM and lymph node metastasis(P<0.05).HER-2/neu/c-erbB-2 expression in poorly differentiated group had a significant difference compared with that in well differentiated group(P<0.01).3. Expression of KAI1 was tested in 29 cases of 60 patients (48.33%) and can also be tested in 10 normal tissues. The expression rates of KAI1 had a inverse correlation with depth of infiltration(P<0.05). KAI1 expression in early colorectal cancer had a significant difference with that in advanced colorectal cancer (P<0.05). Tumor of patients with lymph node metastasis had significantly lower KAI1 expression levels than that without lymph node metastasis (P<0.05).4. The expression rate of DcR3 in the positive HER-2/neu/ c-erbB-2 group is 65.8% which is higher than the negative group(42.9%). The expression rate of DcR3 in the negative KAI1 group is 77.4% which is higher than the positive group(37.9%).5. The expression of DcR3 have a positive correlation with the expression of HER-2/neu/c-erbB-2 (correlation coefficient: +0.3781, P<0.05). The expression of DcR3 have a negative correlation with the expression of KAI1 (correlation coefficient: -0.5114, P<0.05).Conclusions: KAI1 can either be tested in normal tissue or colorectal cancer, but the expression of DcR3 and HER-2/neu can only be tested in colorectal cancer. The expression of DcR3 and HER-2/neu was increased when the colorectal cancer progressed which means they may related to the malignancy of tumor. The expression level of KAI1 is significantly down-regulated in colorectal cancer. DcR3, HER-2/neu and KAI1 may be valuable marker for assessing the prognosis of gastric carcinoma.