Anti-lipid Peroxidation Effects Of Taurine Ganbo In Rats With Alcoholic Liver Disease

AIM:To observe the protection and treatment effects and anti-lipid peroxidation effects of taurine ganbo in rats with alcoholic liver disease.METHODS:A rat model of alcoholic liver disease was established by intragastric infusion of alcohol.75 Male Wistar rats were randomly divided into 5 groups:the blank control group, the model group, the low-dose group, the middle-dose group and the high-dose group. The model group was given dehydrated alcohol (analytic pure,500 mL/L), once a day for 8 weeks. Besides these, the three taurine ganbo groups were also given taurine ganbo once a day for 8 weeks. The blank control group was treated with distilled water by gastric perfusion with the same volume as the model group once a day for 8 weeks. After these treatments, all the rats were killed, and the serum differences of the alanirie aminotransferase (ALT), aspartate amino transferase (AST), triglyceride (TG), total cholesterol (T-CHO),glucose (GLU) circulating IgG against human serum albumin modified by malondialdehyde (MDA-HSA) and the liver pathology were observed among the five groups.RESULTS:A significant increase of ALT(81.53±22.85 vs 55.20±3.76, 58.40±6.37,61.87±8.17 U/L, all P＜0.01), AST (156.47±32.23 vs 118.13±8.64, 131.2±11.63,123.60±7.78 U/L, all P＜0.01) TG(1.26±0.44 vs 0.55±0.07,0.90±0.33, 0.79±0.15 mmol/L, all±P＜0.01), T-CHO(1.42±0.11 vs 1.21±0.17,1.20±0.24, 1.16±0.11 mmol/L, all P<0.01), GLU(6.86±0.67 vs 6.36±0.37,6.29±0.50,6.28±0.21 mmol/L, all P<0.01) in the model group were observed than the blank control group, the middle-dose group and the high-dose group. The ALT(63.67±6.89 vs 81.53±22.85U/L, p＜0.01),AST(131.2±11.63 vs 156.47±32.23U/L, p＜0.01), GLU(6.38±0.66 vs 6.86±0.67 mmol/L, p<0.05) of the low-dose group was lower than the model group. The circulating IgG against MDA-HSA in the model group were higher than the blank control group, the middle-dose group and the high dose group(all p<0.01).②Compared to the control group, the model group had a much heavier lipid accumulation (P＜0.01). The pathology changed degree of the middle-dose group and the high-dose group were lower than the model group (P＜0.05).CONCLUSION:Taurine ganbo can attenuate alcohol-mediated increase in serum ALT, AST, TG and T-CHO levels and exert anti-lipid peroxidation effects in rats with alcoholic liver disease.