| AIM:The study investigated the effect of aceglutamide on concentration of excitatory amino acids in plasma of patients before percutaneous transluminal angioplasty stent insertion.METHODS:①Thirty-two patients (averagely 64.5 years) with intracal or cervical arterial stenosis treated by percutaneous transluminal angioplasty and inserting bracket were selected from January 2005 to June 2006 at Hospital Affiliated to Medical College of Chinese People's Armed Police Forces.8-18 mm stenosis, averagely (12.2±4.5) mm.②Patients were randomly divided into the control group (n =16) and the therapy group (n=16). Patients in the control group received conventional therapy, whereas those in the therapy group received aceglutamide (20 mL) plus saline (250 mL), once a day, for 7 days. Levels of plasma aminoglutaminic acid and aminosuccinic acid were detected at admission,30 minutes before and after surgery by high performance liquid chromatogram.RESULTS:①Stenosis rate was decreased in both groups by digital subtraction angiography (DSA) after surgery (P< 0.01).②Before operation, contents of plasma aminoglutaminic acid and aminosuccinic acid were decreased in both groups, and the content of the therapy group was lower than the control group (P< 0.05). After surgery, the content of control group was higher than in the therapy group (P< 0.01).③Stents were successfully implanted in 32 patients with the success rate of 96.86%. Six months later, blood flow velocity was reduced in stenosis segment in most cases (28/32,87.50%) by transcranial Doppler sonography. Blood flow velocity was increased in three cases (3/32,2.74%) of the control group, which was not treated by angiography.CONCLUSION:The treatment of aceglutamide via i.v. before percutaneous transluminal angioplasty stent insertion can decrease the content of plasma aminoglutaminic acid, resulting in the risk of reperfusion injury after surgery.
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