| Objective:To observe clinical effect of the principle of Supplementing Kidney and Activating Blood on ameliorating the clinical symptoms of kidney deficiency and blood stasis of Coronary Heart Disease(CHD)-angina pectoris and the changes of nitric oxide (NO),endotheli(ET),superoxide dismutase(SOD) before and after the treatment. To illustate the intervention of the principle of Supplementing Kidney and Activating Blood in coronary endothelial function and antioxidant, and evaluate its clinical effect on CHD-angina pectoris, endothelial function and antioxidant activity.Methods:A randomized single-blind controlled clinical trial is adopted.50 patients were choosed who conform to the CHD-angina pectoris standard and TCM syndrome of kidney deficiency and blood stasis from the heart internal medicine department in JiangSu Province Traditional Chinese medicine hospital during April,2008 to February,2010.According to the ratio of 1:1 composition, the patients were randomly divided into the treatment group and the control group.The treatment group was treated with Supplementing Kidney and Activating Blood Prescription beside the western medicine. The paitients were treated 4 weeks as one treatment course. Observe the changes of Chinses symptoms and ET, NO,and SOD before and after the treatment.Results:TCM syndrome:symptom score in both groups were significantly improved(P <0.05),the treatment group improved significantly better than the control group (P<0.01). The total effective rate of Chinese symptoms was 96%,which was significantly higher than that of the control group(68%).There was significant difference between the two groups (P<0.05).NO, ET:NO level in treatment group increased after treatment, and ET level decreased, both of which were significant difference(P<0.01).Between the two groups after treatment, the increase of NO level in the treatment group was higher than that of the control group, and there was statistical difference (P<0.05);The decrease of ET level after treatment in the treatment group was more significant than that of the control group, and there was significant difference(P＜0.01).SOD:SOD level was significantly higher after treatment in the treatment group(P<0.01), and in the control group it was slightly increased(P=0.34);Between the two groups after treatment, The increase of SOD level in treatment group was more significant than that of the control group, and there was significant difference (P<0.01);and the difference between the two groups before and after treatment were significant (P<0.01).Conclusion: Supplementing Kidney and Activating Blood Prescription could effectively ameliorate the clinical symptoms of coronary heart disease, and the symptom score improvement was better than the control group,so it has good clinical efficacy.It could decrease the level of ET, increase the level of NO,SOD,which indicates that Supplementing Kidney and Activating Blood Prescription could improve endothelial function, improve antioxidant capacity, and delay the progress of atherosclerosis.
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