Expressions And Correlation With Radiotherapy's Effect Of Three Kinds Of Genes In Non-small-cell Lung Carcinoma(NSCLC)

Objective To investigate the expressions of XRCC1,DNA-PKcs and PCNA in NSCLC and its relationship to the effect of radiotherapy.Furthermore,to analyze the predict value of radiotherpy effect.Methods There were 62 patients with NSCLC who were treated by 3D-radiotherapy.Before and after the radiotherpy, they were checked by chest enhanced-CT.Evaluate the short-term effect.The expression of XRCC1,DNA-PKcs and PCNA in 62 patients with NSCLC were determined by immunohistochemical method.Analyze the expression results of the three kinds of genes with the short-term radiotherpy effect in 62 NSCLC patients.Results The expressions of XRCC1,DNA-PKcs and PCNA were closely related with short-term effect after radiotherpy in NSCLC. The short-term effect was descent along with enhancement of XRCC1 and DNA-PKcs,and was rised along with enhancement of PCNA.Conclusions These findings indicated that to detect the expressions of XRCC1,DNA-PKcs and PCNA may predict short-term effect of radiotherapy.The three genes may have relationship with radiotheray sensitive in some extent.