The Clinical Study Of The Nourishing-Yin-and-Dredging-Collateral Formula's Intervention In Flammatory Factors Towards Elderly Patients With Matabolic Syndrome

Objective To investigate the safety and effect of decreasing the inflammatory factors in elderly patients with metabolic syndrome typed in Yin deficiency blood stasis treating by the Nourishing-Yin-and-Dredging-Collateral formula.Methods The study includes 69 elderly patients in accordance with western medicine diagnosis standard of MS and TCM diagnosis standard of yin deficiency blood stasis, among which male 55, female 14, age between 60 and 89, randomly being divided,35 into the observation group and 34 into the control group. The observation group is treated by the nourishing-Yin-and-Dredging-Collateral Formula and common western medicine. The control group was treated only by common western medicine.We carry out test of the inflammation factors (CRP,TNF,IL-6) before and after treatment, and make appraisal of the effect of the total points of TCM symptoms, finally conduct the statistic analysis.Results There is no evident statistic difference(P>0.05) between the two groups about the distribution of age, gender, BMI, obesity, hypertension, blood lipid disorder, diabates, and the total points of the TCM symptoms. So they have comparability.The result of the total points of TCM symptoms told us, after treatment the total points of the observation group is lower than the control group, and the efficacy index is higher (51.12±13.07) than the control group (39.23±13.67).There is 2 cases of obvious effect,31 cases of common effect,2 cases of non-effect in the observation group. There is 25 cases of common effect,9 cases of non-effect in the control group. The effect of the observation group outperformed the control group. The result of the inflammation factors told us:the level of CRP,TNF,IL-6 is decreased after treatment in the observation group, and no significant change in the control group, the effect of observation group is better than control group.Conclusion 1. The formula is combinated by the Nourishing-Yin herbs and Dredging-Collateral herbs.This compatibility fit the basic pathogenic principle of Asthenia of Hepatonephric Yin and Chronic Diseases Transforming to Collaterals for elderly patients with MS. It can improve the clinic TCM symptoms; 2.The formula decrease the inflammation factors (CRP,TNF,IL-6),and reduce inflammation in vivo; 3.It's safe and effective towards elderly MS by the Nourishing-Yin-and-Dredging-Collateral formula; 4. The formula can improve hemoendothelial malfunction in elderly MS patients typed in Yin deficiency blood stasis,it also has great significance of delaying senility of the vessels, and preventing from the onset and development of MS and its related cardio-cerebral vascular diseases.