The Clinical Study Of The Nourishing-Yin-and-Dredging-Collateral Formula's Intervention In Chronic Renal Damage Towards Elderly Patients With Matabolic Syndrome

Objective To evaluate the safety and clinical effect of improving the renal function in elderly patients with metabolic syndrome typed in Yin deficiency blood stasis treating by the Nourishing-Yin-and-Dredging-Collateral formula.Methods The study includes 49 elderly patients in accordance with western medicine diagnosis standard of MS,CKD and TCM diagnosis standard of yin deficiency blood stasis,among which male 39, female 10, age between 60 and 87, randomly being divided,25into the observation group and 24 into the control group. The observation group is treated by the nourishing-Yin-and-Dredging-Collateral Formula and common western medicine. The control group was treated only by common western medicine. We carry out lab tests of chronic kidney disease such as SCr,BUN,UA and UPro before and after treatment, and make appraisal of the effect of the total points of TCM symptoms, finally conduct the statistic analysis then evaluate curative effect.The treatment course is 4 weeks。Results There is no evident statistic difference(P>0.05) between the two groups about the distribution of age, gender, BMI, obesity, hypertension, blood lipid disorder, diabates, cardio-cerebral vascular disease,and the total scores of the TCM symptoms. So they have comparability.The result of the total scores of TCM symptoms showed that after treatment the total scores of the observation group is lower than the control group, and the efficacy index is higher (54.2±10.83) than the control group (38.31±7.69).There is 2 cases of obvious effect,22 cases of common effect,1 cases of non-effect in the observation group. There is 18 cases of common effect,6 cases of non-effect in the control group. The effect of the observation group is much better than the control group (P<0.05). The results of the lab test about renal function: the level of Scr,24hupr greatly decreased in the observation group after treatment as well as compared with the control group, the effect of observation group is better than control group; the level of BUN,UA dereased and GFR increased in both groups, but there is no obvious difference between the two; The two groups of integrated effect comparison:There is 12 cases of obvious effect,9 cases of common effect,3 cases of stable,1 cases of non-effect in the observation group, with the total effective 84%; There is 10 cases of common effect,11 cases of stable,3 cases of non-effect in the control group,with the total effective 41.76%. The effect of the observation group is superior to the control group (P<0.05).Conclusion 1. The formula is combinated by the Nourishing-Yin herbs and Dredging-Collateral herbs.This compatibility fit the basic pathogenic principle of Asthenia of Hepatonephric Yin and Chronic Diseases Transforming to Collaterals for elderly patients with MS. It can improve the clinic TCM symptoms; 2.It's safe and effective towards elderly MS by the between the contract Nourishing-Yin-and-Dredging-Collateral formula; 3.The formula dereased the level of SCr,BUN,UA and UPro,and improved glomerular filtration rate.lt can ameliorate the renal function and played an important roal in delaying renal damage further development.Furthermore, it has great significance of preventing from the onset and development of MS and its related cardio-cerebral vascular diseases.