Relationship Between Types Of Tradition Chinese Medicine Syndrome Of Diabetic Peripheral Neuropathy And Neurophysiological Features

Objective:To study the difference between the types of DPN(Diabetic Peripheral Neuropathy) TCM (Tradition Chinese Medicine) and neurophysiological features and to explore the relationship between the type of TCM syndromes and and Neurophysiological changes of DPN patients.Methods:100 cases of patients of DPN were observed by diabetic peripheral neuropathy diagnostic criteria, then according to the study of TCM Syndrome-type object groups, namely, Qi and Yin Deficiency group (A group), phlegm and blood stasis blocking network card (B group), Yang and resistance network card (C group). Healthy volunteers,20 patients in control group were excluded a history of diabetes and various neurological disorders. Conventional Neutromyography examination were used to detect median nerve, ulnar nerve, common peroneal nerve motor nerve conduction velocity (MCV), amplitude of compound nerve action potentials (CMAP),sensory nerve conduction velocity (SCV), amplitude of sensory nerve action potential (SNAP), distal motor latency (DML), posterior tibial nerve SCV, DML, sural nerve SCV, median nerve and posterior tibial nerve F-wave occurrence rate and latency. In accordance with statistical methods, all test results of different syndromes were compared among different groups to explore the correlation between neutrophysiological and TCM disease type.Results:By A, B group, C group, the neutrophysiological parameters were compared between groups (1) Three median nerve, ulnar nerve and common peroneal nerve SCV, MCV gradually slow down, SNAP, CMAP decreased, DML gradually extended, each two groups compared with of the three groups showed P<0.05. (2) Three sets of posterior tibial nerve SCV gradually slowed down, SNAP decreased gradually, DML gradually extended, each two groups compared with of the three groups showed P<0.05. (3) Sural nerve SCV of the three groups gradually slowed down, SNAP decreased gradually, each two groups compared with of the three groups showed P<0.05. (4) median nerve, posterior tibial nerve F-wave latency of three groups gradually extended, each two groups compared with of the three groups showed P<0.05, F-wave occurrence rate of median nerve and posterior tibial nerve in C group decreased significantly compared with those in A, B group. (5) Detected nerve SCV, MCV, DML in the patients of DPN are damaged compared with D group, but the difference of the median nerve SNAP, MCV, DML and ulnar nerve SCV, MCV between A group and D group showed no statistically significant (P> 0.05). (6) The median nerve and the posterior tibial nerve F-response of DPN patients in each group showed significantly prolonged that P<0.05 compared with D group; the median nerve and the posterior tibial nerve F-wave occurrence rate in C group decreased, their P<0.05 compared with D group.Conclusion:Nerve conduction velocity and F differences in response to each indicator, including SCV, SNAP, MCV,CMAP, DML and F-wave latency in different TCM types of DPN patients were significantly different, and the difference may provide an objective frame of reference for medical practitioners in TCM Syndrome typing of DPN.