AECOPD Airway Epithelial Cell Injury In Clinical Research And Detection

Objective The purpose of this study through the exploration of chronic obstructive pulmonary disease, pulmonary disease with acute exacerbation and stable phase characteristics of TCM and the dialectical norms, so as to further study the laws of Chinese medicine treatment. In symptom research, the preliminary conclusions based on the use of Chinese medicine formulations Cough mixture in the treatment of acute exacerbations of COPD, as soon as possible to relieve symptoms, and through clinical symptoms, signs and laboratory parameters related to the detection and serum IL-4, IL-8, TNF-α, CC16 concentration of detection, further validation of the efficacy of Cough mixture.Methods Chinese medicine according to the relevant standard-setting COPD clinical observation forms were collected 94 cases diagnosed in patients with COPD. Recorder of acute exacerbation and remission of clinical symptoms, diagnostic criteria according to traditional Chinese medicine TCM syndromes classification, statistics and analysis of COPD patients with acute exacerbation and remission of symptoms, symptom characteristics, and to conduct COPD lung function severity classification, explore different severity of COPD patients with acute exacerbation and remission symptom characteristics. To choose with chronic obstructive pulmonary disease with acute exacerbation cases of 94 patients with diagnostic criteria, using the method in which randomized controlled Chinese herbal compound treatment group (50 cases) and western medicine treatment group (44 cases) group were given oral cough and asthma Chinese herbal compound mixture, western medicine group were given oral cephalosporins, the same treatment more than two groups. Course of treatment were 12 days. Before and after treatment were observed in patients with clinical symptoms, signs, chest X ray, pulmonary function, and traditional Chinese medicine syndromes points and were analyzed. Using ELISA method COPD acute and remission in patients with serum IL-4, IL-8, TNF-α, CC16 concentration detection.Results 1, COPD patients with acute exacerbation of ferrite in the spleen and kidney three dirty wasting lung, based on the multi-line due to lung disease recurring, persistent unhealed and chronic illness lung deficiency, phlegm obstruct overflow, caused by reduced pulmonary Convergence, gas ring lung, the lung puffiness, every sense of exogenous evils caused by re-attack or exacerbate illness. In the COPD severity classification, the frequency of each symptom according to the level of order, and overall quite. The remission is based on three dirty lung spleen and kidney qi deficiency, yang deficiency, yin deficiency as the main performance, accompanied by congestion, phlegm and other resistance standard mixture of real and the reality to virtual-based and stage of disease. In this study, the frequency of deficiency were:Qi Deficiency, Spleen Qi Deficiency Syndrome, Kidney-Yang Deficiency, Kidney-Yang Deficiency, Lung-Yin Deficiency. Evidence as follows:blood stasis, phlegm-heat syndrome, phlegm-heat retention in the lung disease, pulmonary disease resistance phlegm. Although the incidence of deficiency in COPD slightly different among the different levels, but begin with the lung spleen and kidney qi deficiency and yang deficiency of mainly Yin were relatively small.2.By detecting the serum of patients with AECOPD in IL-4,IL-8,TNF-a increased the acute phase compared with remission (P<0.05);CC16 concentrations compared with COPD in remission (P<0.05) lower.3. With a serious illness classification, patients with serum IL-4, IL-8, TNF-αlevels increased, CC16 content decreases.4.Chinese medicine treatment group than in western medicine group serum IL-4, IL-8, TNF-αshowed no difference (P>0.05). Traditional Chinese medicine than western medicine treatment group CC16 concentration difference between the treatment group, (P<0.05).Conclusion:AECOPD phlegm cough mixture in treating the lung than simply obstruct the use of western medicine in the shorter course of disease, improve the efficacy of a significant effect, further confirmed that heat discharge method is a treatment of lung Huatanzhike AECOPD phlegm obstruct the lung effective and safe method. Patients with acute exacerbation of COPD in IL-4, IL-8 and TNF-αconcentration, CC16 concentration decreased, as acute exacerbation of COPD airway inflammation injury indicators; cough mixture can be widely promoted in clinical.