The Study On The Relationship Between Endothelium Dysfunction And The HuiZhuoTanZu Syndrome Of Coronary Heart Disease

Objective:The aim of this study is to investigate the plasma level of Endothelin(ET) and Thrombomodulin(TM), so as to explore the relationship between CHD HuiZhuoT- anzhu Syndrome and endothelium dysfunction, provide the microcosmic objective basis for working out the diagnose standard for the coronary heart disease HuiZhuoTanZu Syndrome, in order to make its diagnose tend being externalization. Methods: A total of 172 samples were obtained from 84 cases of CHD huizhuotanzu syndrome and 88 cases of CHD non-huizhuotanzu syndrome, 78 cases of normal controls, then observe and analyses the general data and the plasma level of ET,TM among three groups. Results: 1) Comparison of plasma ET: Compared with normal controls, the lever of ET of CHD HuiZhuoTanzhu Syndrome group and non-HuiZhuoTanzhu Syndrome group are significantly higher, the difference is statistically significant (P<0.01 ); between CHD HuiZhuoTanzhu Syndrome group and the non- HuiZhuoTanzhu Syndrome group, there is a significant difference in the lever of ET (P<0.05). 2) Plasma TM level in comparison: the lever of TM in CHD HuiZhuoTanzhu Syndrome group and non- HuiZhuoTanzhu Syndrome group are higher than healthy control group, the difference is significant (P<0.01), and the lever of TM in CHD HuiZhuoTanzhu Syndrome group is higher than non-HuiZhuoTanzhu Syndrome group (P<0.05). Conclusion:The essence of CHD HuiZhuoTanZu syndrome is huizhuo resistance in the veins Road, closed resistance blood,result in phlegm and blood stagnate in the body, the microcosmic performance is that the levers of ET and TM has increased, there are obvious endothelium dysfunction state in the CHD HuiZhuoTanZu syndrome than non-HuiZhuoTanZu syndrome.The increasing contents of ET,TM can help us to differentiate the CHD HuiZhuoTanZu syndr- omee and non-HuiZhuoTanZu syndrome.