Risk Factors For Food Alleryof Infant

Objective: To analysis the influential factors of food allergy in infants and young children, understanding the relationships between food allergy and the risk factors of food allergy.Methods: Totally 603 normal children and their parents were selected from Department of Primary Child Health Care, Children's Hospital of Chongqing Medical University from January to February in 2009. A survey about risk factors of food allery was taken from their parents, and all of the children took the skin prick test (SPT). Then according to their medical history and results of SPT, elimination test and open food challenge were done to some children. (2) Univariate logistic regression was used to analysis the total sample,pure milk-fed infants and children exposed to other food antigens,then multifactor logistic regression analysis was used according to the results of univariate factor analysis; After controlling family history of food allery, significant influence factors were acquired by univariate factor analysis , then Mantal-Haenszel chi-square test was used to analysis the relationship between food allergy and influence factors.Results: (1) 572 children had completed the questionnaires and diagnostic tests. The total sample data of multivariate logistic regression analysis showed that feeding patterns of the first 4 months, Probiotic supplementation, and Exposure to other food antigen were significant factors to food allergy in infants and children (P <0.05). with food allergies as the dependent variable, Univariate logistic regression analysis in 219 infants of pure milk-fed showed that 8 factors involved were not statistically significant. Multivariate logistic regression analysis in 353 infants who had exposed to other food antigens showed that family history of allergies, suspect allergies history of infant herself (eczema or atopic dermatitis), and the age when exposed to other food antigens were main factors affecting food allergy (P <0.05). (2) Stratified chi-square test showed that pure human milk feeding infants suffering 3.312 times of food allergy risk than that of non-pure human milk-fed (P <0.01,RMH =3.312), and probiotic supplementation could increases the risk of allergy (P <0.01, RMH = 2.679) , and vitamin A and D supplementation to other food antigen had no significant difference (P> 0.05),while the age when exposed to other food antigen had no significant difference(P> 0.05), neither 4-6 months or none 4-6 months.Conclusions: (1) Exposure to other food antigen and exposure time of other food antigen are risk factors of food allergy. (2) Pure human mild feeding, probiotic supplementation and exposure age of other food antigen can not decreased food allergy. Delaying the time expose to other food antigen in early infant can not decrease food allergy.