The Research On Sport And Active Peptide Adorning PLL-PLA Nano Delivery Drug's System To Liver Cancer Targetment

The malignant tumor is one kind of disease that threaten the human health seriously,the curative effect of the operation is difficult to reach an ideal for later period's cancer of Changed and recrudesced broadly;Prompt with biological treatment development,the targeted treatment of the cancer is becoming the focal point that people shows solicitude for gradually.The targeted treatment is strong to curing peculiarity;it's effect is nothing or less for regular cell, while killing cancer's cell. Under the intensity of specifical sport,we mainly reaserch the different sport time cause the effect for the target of liver cancer in this experiment, aiming at raising the treating effect medicine of the medical targetment,and offer a new cured method for cancer's treatment. Experimental method: 64 female ICR small rats are devided averagely into four larger groups by random. While the model of the liver cancer are found;then,every larger groups are divided equally into again two smaller groups-24h groups and 48h groups.Contral groups (C groups): (a) Contral groups 24h (C-24h groups)(b) Contral groups 48h (C-48h groups)Drug groups (D groups): (a) Drug groups 24h (D-24h groups)(b) Drug groups 48h (D-48h groups)Sport10min groups (S10 groups): (a) Sport10min groups 24h (S10-24h groups)(b) Sport10min groups 48h (S10-48h groups)Sport 20min groups (S20 groups): (a) Sport20min groups 24h (S20-24h groups)(b) Sport20min groups 48h (S20-48h groups)Injecting medicine by the tail's vein;C-24h groups and D-24h groups are mean to be killed in the eighth day after injecting Sodium Chloride and medcine.C-48h groups and D-48h groups are mean to be killed in the ninth day after injecting Sodium Chloride and medcine.S10-24h groups and S20-24h groups are mean to state sport for seven days after injecting medcine,then is killed, sport time is 10min and 20min separately and the times of sport is one time.S10-48h groups and S20-48h groups are mean to state sport for seven days after injecting medcine, then is killed,sport time is 10min and 20min separately and the times of sport is one time.In the course of the experiment C groups injected Sodium Chloride for one time,D groups,S10 groups and S20 groups injected medcine for one time.Experimental result:1.the live cancer's medical concentration of D-24h groups distri- bute don't obviously higher than D-48h groups(P>0.05),the compared end of S10-24h groups and S10-48h groups,S20-24h groups and S20-48h groups is the same to the compared end of D-24h groups and D-48h groups,this indicate that the different time's sport isn't influence on the concentration of drug after injecting drug.2.the live cancer's medical concentration of S20 distribute obviously higher than D(P<0.01).and S20 higher than S10(P<0.05),under proper intensity of sport,following increasment of sport time,it indicate that the medicine concentration that liver cancer's has the increasing's trend.the drug carrier delivery systerm strengthen targetment for liver cancer.Conclude: Proper sport can strengthen DHAQ-PLL-PLA-RGD-NP'targetment for liver cancer.one of it's effectual mechanism may be that increase NO and VEGF's expression NO,VEGF and alpha(v)beta(3) are interactive each other among them.NO can arouse the rising expression of VEGF,alpha(v)beta(3). furtherly, urging the more DHAQ-PLL-PLA-RGD-NP combine with alpha(v)beta(3),and strength it's targetment...