Study On Nutritional Intervention Of Type 2 Diabetes Drugs

1 Influence of Different Component Staple Food on Blood Glucose and Lipid in Patients with Type 2 Diabetes MellitusObjective To compare the effect of different staple food on anthropometry, blood lipids, HbAiC, blood glucose and insulin levels in patients with type 2 diabetes mellitus.Methods We recruited 217 patients with T2DM into this study, and divided them into 2 groups (144 participants in the experimental group and 73 in the control group) randomly. The staple food of the test group is composed of wheat flour and several kinds of medicine edible food, which is wheat flour and wheat fiber in the control group. The study lasted 13 weeks. The result of anthropometry, hematological examination, blood glucose and insulin level and their area under the curves before and after the intervention was compared.Results Compared with the experimental group, the patients in control group have better systolic blood pressure (P=0.031) and 2-hours postprandial insulin (P=0.049) results in the 13rd week. Compared with the baseline, the level of body weight, BMI, waist and hip circumference, systolic blood pressure, HDL-C, HbA1c,1-hour and 2-hours postprandial glucose, area under the curve of glucose are all reduced after intervention in both two groups. In addition, diastolic blood pressure (P=0.001), total cholesterol (P=0.004), triglyceride (P=0.020), fasting blood insulin (P=0.029) and 2-hours postprandial insulin (P=0.001) and area under the curves of insulin (P=0.005) declined in the test group, fasting blood glucose (P=0.038) improved in the control group. By calculating the differences of each index variation beforeand after the experiment, the triglyceride (P=0.009) improves in the experimental group and the fasting blood insulin(P=0.021) is better in the control group.Conclusions Compared with the control group, the patients in experimental group have better total cholesterol and triglyceride results. And the fasting insulin level,2-hours postprandial insulin and area under the curves of insulin are decreased. While the reduction of fasting blood glucose are lower in patients of the control group.2 Effect of Edible Medicinal Food Compound Preparation on Blood Glucose in Patients with Type 2 Diabetes MellitusObjective To evaluate the effect of edible medicinal food compound preparation, a new type dietary intervention on blood glucose and blood lipids in patients with type 2 diabetes mellitus.Methods 146 patients with T2DM joined and completed this study, they were randomly divided into interventional group and control group with the ratio of 2:1,96 participants in the interventional group and 50 in the control group. The study lasted 13 weeks, patients mixed 5 grams edible medicinal food compound preparation or placebo with hot water, intake it before each meal. Anthropometry, blood lipids, HbAlC, blood glucose and insulin were measured before and after the intervention.Results In the 13rd week, compared with the control group, the level of 0.5-hour (-P=0.001) and 1-hour (P=0.035) postprandial glucose,1-hour postprandial insulin (P=0.001), area under the curves of insulin (P=0.004) are lower in patients of the experimental group. Compared with the baseline, the level of waist circumference (P=0.001), triglycerides (P=0.028), HbA1c(P=0.001),0.5-hour (P=0.001),1-hour (P=0.001) and 2-hours (P=0.001) postprandial glucose, area under the curves of glucose (P=0.001) reduced and the level of fasting blood insulin (P=0.031) improved in the interventional group. In the control group, HbA1c (P=0.012) and fasting blood glucose (P=0.005) declined,0.5-hour postprandial glucose (P=0.001),0.5-hour (P=0.001) and 1-hour (P=0.006) postprandial glucose, area under the curves of insulin (P=0.006) increased. By calculating the differences of each index variation beforeand after the experiment, the fasting (.P=0.014),0.5-hour (P=0.001) and 1-hour (P=0.001) postprandial glucose, area under the curves of glucose (P=0.001) decreased more in the interventional group.0.5-hour (P=0.001) and 1-hour (P=0.015) postprandial insulin, area under the curves of insulin (P=0.018) are higher in the control group.Conclusions Compared with the placebo, edible medicinal food compound preparation has a better effect on waist circumference, triglycerides and postprandial plasma glucose in T2DM.