Molecule Imprinting Technology And Its Research Progress

Molecular imprinting technology (MIT for short) is a novel chemical analysis technology.This technology originated in the90s, is the application of supermolecular chemistry category,which is been provided with molecular recognition, segregation, macromolecular syntheses,the simulation of engineering and other multi-disciplinary field combined with more than aborderline branch discipline,In1940, the Nobel Prize winner Pauling tried to reference key theory to explain inimmune system, in other words, it is a method of synthetic antibody antigen molecule.Scientists put forward the "molecular imprinting" using of his theory after a long-term researchin1949. A kind of polymer compounds was been prepared such as Wullf in1973, the polymercompounds could choose better identification of sugars and amino acids. Molecular imprintingtechnology widely used in medicine, environment, food, military and so on. Most of scholarsengaged in molecular imprinting technology in the United States, Japan, China, Sweden andGermany. Molecular imprinting technology is increasingly mature in recent years. There aremore and more reviews, books, essays, papers, especially the specific application ofmolecular imprinting technique is a qualitative leap. This paper introduced the contents asfellows.The basic principle of molecular imprinting is to join the imprinting molecular andfunctional monomer in a certain solvent, relying on the non-covalent bond or covalent bondforms between forming complexes, and then add the crosslinking agent to make molecularlyimprinted polymer. This technology can detect, analyze, separate, etc. effectively. Thepolymer are relative to natural material, which have the same recognition ability, and has moreresistance to high temperature and high pressure, strong acid and alkali salt resistance,resistance to the stability of the bad environment, and the material can be reused repeat, somolecular imprinting technology have characterization of preordainment, higher identifiabilityand practicability. Molecularly imprinted polymer can be divided into covalent andnon-covalent method and half covalent method. Preparation of molecularly imprinted polymershould consider imprinting molecule and functional monomer, pore-making agent,crosslinking agent and solvent selection and using ratio. General polymerization methods oftenhave standard polymerization, in-situ polymerization and precipitation polymerization,suspension polymerization and surface imprinting, electrical aggregation. Each method has itsadvantages and disadvantages, according to the actual situation to choose different preparationmethods. The paper mainly introduced the application of molecular imprinting technique toseparate areas (which can be divided into solid phase extraction and chiral separation,membrane separation and pharmaceutical analysis), antibody receptors in simulation,biomimetic sensors, mimic enzyme catalysis and other applications. In recent years, themolecular imprinting technology develops quickly. New progress of molecular imprintingtechnology in the aqueous solution of the molecularly imprinted polymer briefly discusses in the fifth chapter, surface molecular imprinting, trace detection and several kinds of newmaterials. The recent emergence of the basic principles, steps and characteristics of ionimprinted polymer, preparation methods, this paper also made a simple introduction. Finallythe problems of molecular imprinting technique were made a brief summary and expectation.