Preparation And Drug Carrying Property Of Dextrin Nanoparticles

Dextrin microspheres (DMS) are prepared with dextrin that is well known merchandise, and DMS is easily degradable and could be widely used biological agent. As a drug carrier, DMS has good sustained release function to improve the cure effect. This thesis is focused on an approach to drug sustained release and degradation of dextrin nanoparticles (DNP).DNP were prepared from dextrin by inverse emulsion with trisodium trimetaphosphate as the crossing-linking agent, Span-60and Tween-60as the emulsifying agent, and n-hexane as the organic phase. DNP was packed with aspirin as the drug to examine the drug carrying property. UV spectrophotometry was used to analyze the sustained release effect of the drug-packed DNP. The influences of preparation conditions were observed on adsorption quantity of DNP. An orthogonal experiment was conducted for optimizing the DNP preparation conditions with drug packing. The drug sustained release of drug-packed DNP was also studied in different medium, and the degradation of DNP studied in medium simulating human body.The drug packing quantity of DNP had different results with different dosages of crosslinking agent. As dosage of crosslinking agent was less than0.012g, the drug packing dosage was decreased. When dosage of crosslinking agent was more than0.012g, the drug packing dosage was also decreased. Therefore0.012g of crosslinking agent was the best dosage. As the dosage of cosurfactant n-pentanol was increased, the drug packing dosage was decreased. Therefore the best dosage of cosurfactant n-pentanol was about15mL. As the dosage of water phase was increased, drug packing dosage of dextrin nanoparticles was decreased until water phase reached to35mL.Therefore the better water phase dosage was25mL per100mL oil phase. The drug packing dosage of DNP was increased significantly with dosage of drug increased. A better dosage of drug was about50mg. The carrying capability of DNP was increased with the decrease of dextrin solution when preparing, and a better dosage was about2%. Influence order of conditions preparing DNP on drug packing dosage quantity of DNP was drug dosage>dextrin solution>dosage of crosslinking agent>dosage of cosurfactant n-pentanol>dosage of water phase. Optimum condition for preparing DNP was0.012g of crosslinking agent,16mL of cosurfactant n-pentanol, O/W100/25,70mg drug,2%of dextrin solution. When drug-packed DNP under37℃in three kinds of buffers PBS, PS, HCl, drug was released fast within24h, then slow released. And it’s release rate was increased with the increase of degradation time in artificial intestinal juice and artificial gastric juice.The research showed that DNP showed it could be used to serve a drug carrier with good drug sustained release.