Study On The Preparation And Quality Standards Of HCHH Xiqing Soft Capsules

Qinghai Province lies in the Northeast of Qinghai-Tibet Plateau, because of its special topography and ecological environment,the species is abundant. Pure nature medical plant and materials in Qinghai-Tibet Plateau mostly grow under cold, arid and intense ultraviolet ray enviroment, which extremely are in strong vitality and activeness, medicine articles quality are also good. HCHH is one of the major variety of local medical ch, use for disease treatment extensively. HCHH, commonly called as " the sub root of the wild Chinese scholartree ", belongs to plant Latin name for Umbelliferae ch, is mainly produced in some areas in Qinghai Province and the Northwest. Put forward about development of traditional Chinese medicine industry area, characteristic ethnic minority drugs’overall goal that study according to " The Eleventh Five-Year Science and Technology Support Plan " confirm this characteristic crude drugs to set up the question to study to northwest HCHH..Subject was based on the main goal that develop the new medical position of the crude drugs and utilize on the ground HCHH especially.However, Research is the first attempt,which study on pharmaceutical formulations and quality stadard.1 Pharmaceutical formulationsBecause there is less domestic and international study on HCHH.The corresponding documents and materials is scarcity.Screening test,prediction are used for the first time in advance, get extraction rate as evaluation index of pharmaceutical formulations with rutin, total flavonoids content..We adopt the orthogonal test to select the best craft of extracting progress:Soak the 85% ethanol of crude drugs for an hour, extract for 3 times,2 hour total,add respectively ten times, octuple, octuple solvent to each time. Modern purified technology-macroporous absorption resin combining static and dynamic adsorbing, adsorption dynamics theory pick up D-101 resin for purity of crude drugs extracts.Soft capsules shell constituent mix gelatin, water, glycerine and pigment in proportion.The diluent choose PEG-400, adding 1% Tween 80 and right amount of glycerine.2 Quality standardLatin name was identified by TLC. The content of total flavonoids was determined by the UV/VIS spectrum and the average recovery was 99.9% and was 1.55%. The content of rutin was deterimined by HPLC and the average recovery was 99.45% and was 1.55%. The method is simple, accurate, reproducible and can be applied for quality control.