Study Of The Electrospinning Ploylactied Nanofibrous Membrane Modified By Graphene

Skin is vital component in human body. It has closely linked with body temperature,immunity, sensing outside and other important functions. Trauma is a kind of disease which cannot afford to ignore, so wound dressing is always indispensable in both living and field of medicine. However, traditional wound dressing no longer satisfies our needs,so degradable biologic dressing becomes research emphasis in recent years. Polylactic acid is widely applied in the field of biological medicine which has incomparable biodegradability, biocompatibility and certain strength. Recently, there are so many researches on antibacterial property of graphene and its cytotoxicity. The results show that graphene has great antibacterial effect and avirulence to cells. At the same time, grapheme oxide also owns excellent hydrophilic property, which all provides solid theoretical basis for application in the field of biological medicine. Up to now, we still have not found relevant report on making graphene into polylactic acid by electrospinning to apply to biological wound dressing.In this paper,we produce graphene modified polylactic acid nanofiber membrane by electrospinning.Then we explores the influence of graphene on membrane properties of nanofiber and its probable utilization on biological wound dressing.Firstly, we use Interlayer catalytic exfoliation(ICE)to produce graphene and do texts such as SEM,TEM,FTIR,Raman,XRD. The results show that graphene has larger size and its thickness is less than 2nm. Finally, we get flawless graphene which keeps its intact basic crystal planes.And then, we do technological discussion on electrospinning of polylactic acid andreach the following conclusion: environmental parameter: temperature is 25 ℃, relative humidity is 25%, and the concentration of spinningfluid is 15%. Processive technological parameter: voltage is 15 kV, feeding speed is 0.5ml/h, horizontal distance between needle to gathering unit is 15 cm. Use silver paper as final gathering unit. By applying this technological parameter to spin out graphene modified polylactic acid nanofibrous membrane, and doing SEM and TEM texts on single fiber, the results show that graphene is packed inside the fiber. And then we do FTIR and Raman texts on nanofiber membrane,the results show that membrane contains graphene again.Finally, we discuss the antibacterial properties of composite membrane.The results of antibacterial rate test show that graphene owns no antibacterial properties, while bacteriostasis rate of graphene oxide is over 90%. Then we do inhibition zone tests on nanofiber membrane,and the results show that composite membrane containing graphene has no bacteriostasis circle while composite membrane containing graphene oxide has a small circle of bacteriostasis circle. The circle is quite tiny, maybe because of little content of graphene oxide in the membrane.